Thy-1,2 +细胞在严重缺氧时造血调节中的作用

Role of Thy-1,2+ cells in the regulation of hemopoiesis during severe hypoxia.

作者信息

Goldberg E D, Dygai A M, Zyuz'kov G N

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2007 Jan;143(1):18-21. doi: 10.1007/s10517-007-0006-1.

DOI:10.1007/s10517-007-0006-1

PMID:18019003

Abstract

We studied the state of the bone marrow Thy-1,2+ cell pool under conditions of severe hypoxia. T cell mechanisms of hemopoiesis regulation are preserved under conditions of severe oxygen deficiency due to changes in functional properties of Thy-1,2+ cells. We revealed an indirect (mediated through cooperation with adherent myelokaryocytes) stimulating effect of Thy-1,2+ cells on erythroid precursors as well as direct and indirect feeder effects of these cells on granulocyte-monocyte precursors.

摘要

我们研究了严重缺氧条件下骨髓Thy-1,2+细胞池的状态。由于Thy-1,2+细胞功能特性的改变，造血调节的T细胞机制在严重缺氧条件下得以保留。我们揭示了Thy-1,2+细胞对红系前体细胞的间接（通过与黏附性骨髓核细胞合作介导）刺激作用，以及这些细胞对粒细胞-单核细胞前体细胞的直接和间接饲养细胞作用。