Yoshino Hideaki, Toda Narihiro, Kobata Masami, Ukai Katsumi, Oshima Koichiro, Utimoto Kiitiro, Matsubara Seijiro
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoudai-katsura, Nishikyo, Japan.
Chemistry. 2006 Jan 11;12(3):721-6. doi: 10.1002/chem.200500767.
Bis(iodozincio)methane, prepared from diiodomethane and zinc, reacts with an organic halide in the presence of a transition-metal catalyst to give an iodozinciomethylenated compound; this then reacts with another organic halide to form a C--C bond. The overall process connects two electrophiles with one carbon atom. Bis(iodozincio)ethane can also undergo this transformation, yielding a new stereogenic center. The asymmetric induction of this stereogenic center was investigated by using a chiral palladium catalyst.
由二碘甲烷和锌制备的双（碘锌基）甲烷，在过渡金属催化剂存在下与有机卤化物反应，生成碘锌基亚甲基化化合物；该化合物再与另一种有机卤化物反应形成碳 - 碳键。整个过程通过一个碳原子连接两个亲电试剂。双（碘锌基）乙烷也能发生这种转化，产生一个新的手性中心。使用手性钯催化剂研究了这个手性中心的不对称诱导作用。
