Wirz Stefan, Klaschik Eberhard
Department of Anesthesiology and Intensive Care Medicine, Outpatient Pain Clinic, University of Bonn, Germany.
Am J Hosp Palliat Care. 2005 Sep-Oct;22(5):375-81. doi: 10.1177/104990910502200511.
This study assessed the efficacy of laxative use for treatment of constipation in patients receiving opioid therapy, with special attention to polyethylene glycol 3350/electrolyte solution (PEG-ES). Computerized data from 206 patients were analyzed using descriptive statistics. Subgroups were analyzed using confirmatory statistics. Constipation occurred in 42.7 percent of patients. Laxatives were administered to 74.3 percent of these patients using a standardized step scheme, with good results in 78.4 percent. As a therapy for constipation, the combined administration of PEG-ES, sodium picosulphate, and liquid paraffin proved most effective, although statistical analysis yielded no significance. Early use of PEG-ES using a step scheme holds promise for treatment of opioid-related constipation in palliative care patients, although further investigation is warranted.
本研究评估了在接受阿片类药物治疗的患者中使用泻药治疗便秘的疗效，特别关注聚乙二醇3350/电解质溶液（PEG-ES）。使用描述性统计分析了来自206名患者的计算机化数据。使用验证性统计分析亚组。42.7%的患者发生便秘。这些患者中的74.3%使用标准化阶梯方案给予泻药，78.4%效果良好。作为便秘的治疗方法，PEG-ES、比沙可啶钠和液状石蜡联合使用被证明最有效，尽管统计分析未得出显著结果。采用阶梯方案早期使用PEG-ES有望治疗姑息治疗患者的阿片类药物相关性便秘，尽管仍需进一步研究。
