Lu Juan, Cao Qin, Wang Xiaochun, Pu Jianbin, Peng Xuelian
Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Am J Ther. 2016 Jul-Aug;23(4):e1020-4. doi: 10.1097/MJT.0000000000000351.
The aim of the study was to investigate the efficacy of combined application of lactulose oral solution and polyethylene glycol electrolyte powder compared with conventional method in preparing for colonoscopy bowel cleanliness in patients with constipation. Ninety patients, who had constipation and needed to have colonoscopy, were divided into study group and control group with 45 cases in each group, respectively. One day before the colonoscopy, patients in the experimental group were given lactulose oral solution and polyethylene glycol electrolyte powder, whereas the patients in the control group were given oral polyethylene glycol electrolyte powder only. The following parameters were then obtained: time of the first defecation (duration of the time from taking the drugs to the first bowel movement), defecation frequency, completion of bowel cleaning (duration from the first bowel movement to the stool becoming clear), and adverse reaction. Cleansing effect in the study group bowel preparation was significantly better than that in the control group (P < 0.05). Specifically, time of the first defecation and completion of bowel cleaning were statistically shorter in the study group than those in the control group (P < 0.05), and defecation frequency was significantly higher in the study group than that in the control group (P < 0.05). Incidence of adverse reaction, however, was not significantly different between the 2 groups (P > 0.05). Combined application of lactulose oral solution and polyethylene glycol electrolyte powder is superior to the conventional method of polyethylene glycol electrolyte powder alone for colonoscopy bowel preparation in patients with constipation. Therefore, combined clinical application of the 2 compounds is strongly recommended for colonoscopy bowel preparation in patients with constipation.
本研究旨在探讨乳果糖口服溶液与聚乙二醇电解质散联合应用相较于传统方法在便秘患者结肠镜检查肠道准备中的效果。90例有便秘且需行结肠镜检查的患者，被分别分为研究组和对照组，每组45例。在结肠镜检查前一天，试验组患者给予乳果糖口服溶液和聚乙二醇电解质散，而对照组患者仅给予口服聚乙二醇电解质散。随后获取以下参数：首次排便时间（从服药至首次排便的时长）、排便频率、肠道清洁完成情况（从首次排便至粪便变清的时长）以及不良反应。研究组肠道准备的清洁效果显著优于对照组（P < 0.05）。具体而言，研究组的首次排便时间和肠道清洁完成时间在统计学上短于对照组（P < 0.05），且研究组的排便频率显著高于对照组（P < 0.05）。然而，两组间不良反应发生率差异无统计学意义（P > 0.05）。对于便秘患者的结肠镜检查肠道准备，乳果糖口服溶液与聚乙二醇电解质散联合应用优于单独使用聚乙二醇电解质散的传统方法。因此，强烈推荐这两种化合物联合临床应用于便秘患者的结肠镜检查肠道准备。
