Eklund Lauri, Olsen Bjorn R
Harvard School of Dental Medicine, Department of Oral and Developmental Biology, 188 Longwood Avenue, REB, 4th floor, Boston, MA 02115, USA.
Exp Cell Res. 2006 Mar 10;312(5):630-41. doi: 10.1016/j.yexcr.2005.09.002. Epub 2005 Oct 12.
Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic remodeling process during development, including destabilization of existing vessels, endothelial cell migration, tube formation and the subsequent stabilization of newly formed tubes by mesenchymal cells. Beyond this critical role in blood vessel development, recent studies suggest a wider role for Tie2 and angiopoietins in lymphangiogenesis and the development of the hematopoietic system, as well as a possible role in the regulation of certain non-endothelial cells. The outcome of Tie signaling depends on which vascular bed is involved, and crosstalk between different VEGFs has an important modulating effect on the properties of the angiopoietins. Signaling through the Tie1 receptor is not well understood, but Tie1 may have both angiopoietin-dependent and ligand-independent functions. Changes in the expression of Tie receptors and angiopoietins occur in many pathological conditions, and mutations in the Tie2 gene are found in familial cases of vascular disease.
血管生成素是Tie2受体的配体，以一种依赖于环境的方式控制血管生成重塑。Tie信号通路参与发育过程中血管生成重塑的多个步骤，包括现有血管的不稳定、内皮细胞迁移、管腔形成以及随后间充质细胞对新形成管腔的稳定作用。除了在血管发育中的这一关键作用外，最近的研究表明Tie2和血管生成素在淋巴管生成和造血系统发育中具有更广泛的作用，以及在某些非内皮细胞的调节中可能发挥作用。Tie信号通路的结果取决于所涉及的血管床，不同血管内皮生长因子（VEGF）之间的相互作用对血管生成素的特性具有重要的调节作用。通过Tie1受体的信号传导尚不清楚，但Tie1可能具有依赖血管生成素和不依赖配体的功能。Tie受体和血管生成素的表达变化发生在许多病理状态下，并且在家族性血管疾病病例中发现了Tie2基因的突变。
