Underhill David M
Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Immunity. 2005 Oct;23(4):343-4. doi: 10.1016/j.immuni.2005.09.011.
Toll-like receptors (TLRs) trigger inflammatory signaling in macrophages and enrich on phagosomes, suggesting that TLRs may directly influence phagosome formation and maturation. However, in this issue of Immunity, Yates and Russell use carefully defined particles and quantitative methodology to measure phagosome maturation and find no effect of TLR signaling on the process.
Toll样受体（TLRs）在巨噬细胞中触发炎症信号，并在吞噬体上富集，这表明TLRs可能直接影响吞噬体的形成和成熟。然而，在本期《免疫》杂志中，耶茨和拉塞尔使用精心定义的颗粒和定量方法来测量吞噬体成熟，结果发现TLR信号对这一过程没有影响。
