Pütz Mike M, Alberini Isabella, Midgley Claire M, Manini Ilaria, Montomoli Emanuele, Smith Geoffrey L
Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London W2 1PG, UK.
Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Via A. Moro, 53100 Siena, Italy.
J Gen Virol. 2005 Nov;86(Pt 11):2955-2960. doi: 10.1099/vir.0.81265-0.
Decades after smallpox was eradicated and vaccination discontinued, the level of residual immunity in today's population is largely unknown. This study describes an epidemiological assessment in Italians of antibodies against the intracellular mature virus (IMV) and extracellular envelope virus (EEV) forms of Vaccinia virus. Serum samples (n = 642) were taken in 1993 and 2003 from people between 11 and 102 years old. Most citizens >27 years old were positive for antibodies to IMV and EEV. These antibodies were long-lasting and similar titres were present in citizens between 30 and 100 years old. Serum samples from 1993 and 2003 displayed very similar EEV- and IMV-specific antibody titres. By using these data and demographic considerations, it was predicted that, in 2003, 46 % of the Italian population were positive for both IMV and EEV, 42 % were negative for both and 12 % were positive for one antigen.
天花被根除且停止接种疫苗数十年后，当今人群中的残余免疫水平在很大程度上尚不清楚。本研究描述了对意大利人群中针对痘苗病毒细胞内成熟病毒（IMV）和细胞外包膜病毒（EEV）形式抗体的流行病学评估。1993年和2003年采集了642份11至102岁人群的血清样本。大多数27岁以上的公民对IMV和EEV抗体呈阳性。这些抗体具有持久性，30至100岁的公民中存在相似的滴度。1993年和2003年的血清样本显示出非常相似的EEV和IMV特异性抗体滴度。利用这些数据和人口统计学因素预测，2003年，46%的意大利人群对IMV和EEV均呈阳性，42%两者均为阴性，12%对一种抗原呈阳性。
