ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients.
作者信息
van Dieren J M, van Vuuren A J, Kusters J G, Nieuwenhuis E E S, Kuipers E J, van der Woude C J
出版信息
Gut. 2005 Nov;54(11):1664.
Abstract
摘要
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本文引用的文献
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Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).硫唑嘌呤治疗的药物不良反应与编码肌苷三磷酸焦磷酸酶（ITPase）的基因多态性有关。
Pharmacogenetics. 2004 Mar;14(3):181-7. doi: 10.1097/00008571-200403000-00006.
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Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.肌苷三磷酸焦磷酸水解酶缺乏症的遗传基础。
Hum Genet. 2002 Oct;111(4-5):360-7. doi: 10.1007/s00439-002-0798-z. Epub 2002 Aug 15.
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TPMT in the treatment of Crohn's disease with azathioprine.硫嘌呤甲基转移酶在硫唑嘌呤治疗克罗恩病中的应用。
Gut. 2002 Aug;51(2):143-6. doi: 10.1136/gut.51.2.143.
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Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.巯嘌呤药物遗传学：红细胞硫嘌呤甲基转移酶活性的单基因遗传
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Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism.
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