van Vliet Marion, van Dijke Cornelis F, Wielopolski Piotr A, ten Hagen Timo L M, Veenland Jifke F, Preda Anda, Loeve Antonius J, Eggermont Alexander M M, Krestin Gabriel P
Department of Radiology, Erasmus MC-University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Radiographics. 2005 Oct;25 Suppl 1:S85-97; discussion S97-8. doi: 10.1148/rg.25si055512.
Angiogenesis is a very important process for tumor growth and proliferation. Given its high temporal and spatial resolution, magnetic resonance (MR) imaging is well suited for use in the assessment of angiogenesis. MR angiography can be used clinically and experimentally for identification of tumor feeding and draining vessels, for tumor characterization, and for treatment planning. The morphologic structure of tumor vessels can be investigated in relation to tumor vessel permeability with use of specific contrast agents. To gain insight into tumor angiogenesis in vivo, the authors compared images obtained with digital photography, high-resolution MR angiography, and intravital microscopy through a dorsal skin-fold window in a rodent model. The close correlation between images obtained with these various modalities, with regard to the depiction of the developing tumor vasculature, indicates that noninvasive quantification of angiogenesis may be possible with MR imaging. Future directions in tumor imaging may include so-called four-dimensional MR angiography, in which high-resolution three-dimensional MR angiography is combined with dynamic contrast-enhanced MR imaging.
血管生成是肿瘤生长和增殖的一个非常重要的过程。鉴于其高时空分辨率，磁共振（MR）成像非常适合用于评估血管生成。磁共振血管造影可在临床和实验中用于识别肿瘤的供血和引流血管、进行肿瘤特征分析以及制定治疗计划。使用特定的造影剂，可以研究肿瘤血管的形态结构与肿瘤血管通透性之间的关系。为了深入了解体内肿瘤血管生成情况，作者在啮齿动物模型中通过背部皮肤褶窗比较了数码摄影、高分辨率磁共振血管造影和活体显微镜检查所获得的图像。这些不同成像方式所获得的图像在显示肿瘤血管系统发育方面具有密切相关性，这表明磁共振成像有可能对血管生成进行无创定量分析。肿瘤成像的未来发展方向可能包括所谓的四维磁共振血管造影，即将高分辨率三维磁共振血管造影与动态对比增强磁共振成像相结合。
