Wuisman P, Roessner A, Bosse A, Ueda Y, Winkelmann W, Enneking W F
Dept. Orthopaedics, Westfälischen Wilhelms University, Münster, Germany.
Ann Oncol. 1992 Apr;3 Suppl 2:S33-5. doi: 10.1093/annonc/3.suppl_2.s33.
Seventy-five osteosarcomas at various grades of histologic differentiation were investigated for evidence of osteonectin. According to the results of the study, osteonectin was present in all osteosarcomas. An association between the intensity of the osteonectin antibody reaction and prognosis could not be established. Evidence of osteonectin was also found in other bone tumors. Osteonectin is therefore unsuitable for differential diagnosis, cannot be regarded as a bone specific protein and has not prognostic value.
对75例不同组织学分化程度的骨肉瘤进行了骨粘连蛋白检测。根据研究结果，所有骨肉瘤中均存在骨粘连蛋白。骨粘连蛋白抗体反应强度与预后之间未发现相关性。在其他骨肿瘤中也发现了骨粘连蛋白。因此，骨粘连蛋白不适用于鉴别诊断，不能被视为骨特异性蛋白，也没有预后价值。
