Jane-Lise S, Corda S, Chassagne C, Rappaport L
U127 INSERM, IFR Circulation Paris 7.
Heart Fail Rev. 2000 Oct;5(3):239-50. doi: 10.1023/A:1009857403356.
Cell characteristics and phenotype depend on the nature of the extracellular matrix, the type and organization of integrins and cytoskeleton. The interactions between these components are poorly known at the myocyte level and during cardiac remodeling associated with cardiac hypertrophy and heart failure. We analyze here the nature and organization of extracellular matrix (ECM) proteins, cytoskeleton and integrins and their regulation by growth factors, such as angiotensin II, in normal myocyte growth and in pathological growth (hypertrophy) of the myocardium and heart failure.
细胞特征和表型取决于细胞外基质的性质、整合素的类型和组织方式以及细胞骨架。在心肌细胞水平以及与心肌肥大和心力衰竭相关的心脏重塑过程中，这些成分之间的相互作用尚不清楚。我们在此分析细胞外基质（ECM）蛋白、细胞骨架和整合素的性质和组织方式，以及它们在正常心肌细胞生长、心肌病理生长（肥大）和心力衰竭中受血管紧张素II等生长因子的调节情况。
