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阿根廷布宜诺斯艾利斯变性性工作者中耐多药结核病的暴发

Multidrug-resistant tuberculosis outbreak among transvestite sex workers, Buenos Aires, Argentina.

作者信息

Palmero D, Ritacco V, Ruano S, Ambroggi M, Cusmano L, Romano M, Bucci Z, Waisman J

机构信息

Tuberculosis Multirresistente/SIDA, Hospital Muñiz, Buenos Aires, Argentina.

出版信息

Int J Tuberc Lung Dis. 2005 Oct;9(10):1168-70.

PMID:16229230
Abstract

We describe the first outbreak of multidrug-resistant tuberculosis (MDR-TB) that occurred in Argentina among transvestite sex workers, and actions undertaken for its control. In Buenos Aires city, transmission was documented between 2001 and 2004 by conventional and molecular methods in a hotel where transvestites used to reside and work. The source case was traced back to 1998. Six secondary cases were diagnosed and treated. Thirty-two contacts were investigated. The outbreak strain had formerly caused nosocomial transmission in Rosario, a city 300 km from Buenos Aires. Our findings highlight the difficulties controlling MDR-TB in Argentina.

摘要

我们描述了阿根廷首次在易装癖性工作者中发生的耐多药结核病(MDR-TB)疫情,以及为控制疫情所采取的行动。在布宜诺斯艾利斯市,2001年至2004年期间,通过传统和分子方法在一家易装癖者居住和工作的酒店记录了传播情况。源头病例可追溯到1998年。确诊并治疗了6例二代病例。对32名接触者进行了调查。该疫情菌株曾在距布宜诺斯艾利斯300公里的罗萨里奥市引起医院内传播。我们的研究结果凸显了阿根廷在控制耐多药结核病方面的困难。

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PLoS One. 2013;8(1):e53599. doi: 10.1371/journal.pone.0053599. Epub 2013 Jan 11.
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HIV infection and geographically bound transmission of drug-resistant tuberculosis, Argentina.
HIV 感染与耐多药结核病的地理传播,阿根廷。
Emerg Infect Dis. 2012 Nov;18(11):1802-10. doi: 10.3201/eid1811.120126.
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Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains.耐多药结核病患者针对耐多药结核分枝杆菌M株和Ra株的暴发,表现出Th1反应受损和调节性T细胞水平升高。
Infect Immun. 2009 Nov;77(11):5025-34. doi: 10.1128/IAI.00224-09. Epub 2009 Aug 31.
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Tuberculosis and HIV: a global menace exacerbated via sex trafficking.结核病与艾滋病病毒:性交易加剧的全球威胁。
Int J Infect Dis. 2009 Sep;13(5):543-6. doi: 10.1016/j.ijid.2008.11.010. Epub 2009 Jan 18.