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用于生物芯片和微流控平台荧光光谱分析的垂直腔半导体器件。

Vertical-cavity semiconductor devices for fluorescence spectroscopy in biochips and microfluidic platforms.

作者信息

Porta P A, Summers H D

机构信息

Cardiff University, School of Physics and Astronomy, 5, The Parade, Cardiff, CF24 3YB Wales, United Kingdom.

出版信息

J Biomed Opt. 2005 May-Jun;10(3):034001. doi: 10.1117/1.1925229.

DOI:10.1117/1.1925229
PMID:16229645
Abstract

This paper describes the properties of vertical-cavity semiconductor devices designed to emit light when driven in forward bias mode and detect optical radiation at wavelengths longer than that of emission when driven in reverse bias mode. The study of this type of devices is motivated by the miniaturization and integration into a single unit of the three functions that a microfluorimeter has to perform, optical pumping, optical detection, and optical filtering of weak light sources. The devices produced can generate fluorescence with a low output power since their emission wavelength can be tuned with that of maximum absorption of the fluorescent dye. We demonstrate also that they can detect low power fluorescence generated in a small volume of concentrated solution of a commercial dye. These devices can find useful application in microanalytical systems such as microfluidic devices or optical biochips.

摘要

本文描述了垂直腔半导体器件的特性,这些器件在正向偏置模式下驱动时发光,在反向偏置模式下驱动时检测波长比发射波长更长的光辐射。对这类器件的研究是由微荧光计必须执行的三项功能(光泵浦、光检测和弱光源的光滤波)的小型化并集成到单个单元中所推动的。所生产的器件能够以低输出功率产生荧光,因为其发射波长可以与荧光染料的最大吸收波长相匹配。我们还证明了它们能够检测在少量商用染料浓缩溶液中产生的低功率荧光。这些器件可在诸如微流控器件或光学生物芯片等微分析系统中找到有用的应用。

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