Krishnaswamy Narayan, Srinivas T, Rao G Mohan
Department of Instrumentation and Applied Physics, Institute of Science, Bangalore 560012, India.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:30-4. doi: 10.1109/IEMBS.2011.6089889.
Sensitivity analysis is an important aspect to be looked into while designing lab-on-a-chip systems. In this paper we will be showing with appropriate design that the best sensitivity of the fluorescence biosensor is achieved for an optimal width of fluidic gap, corresponding to a particular mode spot size. We will be also showing that the sensitivity of the biosensor is affected by efficiency of light coupling, which is influenced by changes in the width of fluidic gap, refractive index of the fluid and higher order modes.
在设计芯片实验室系统时，灵敏度分析是一个需要深入研究的重要方面。在本文中，我们将通过适当的设计表明，对于与特定模式光斑尺寸相对应的最佳流体间隙宽度，荧光生物传感器可实现最佳灵敏度。我们还将表明，生物传感器的灵敏度受光耦合效率的影响，而光耦合效率又受流体间隙宽度、流体折射率和高阶模式变化的影响。
