Claussen D
Gastroenterol Nurs. 1992 Jun;14(6):307-9. doi: 10.1097/00001610-199206000-00007.
The largest nationwide comparative clinical study evaluated 337,647 patients receiving high-osmolar ionic contrast media or low-osmolar nonionic contrast media and the incidence of adverse drug reactions. The overall prevalence of adverse drug reactions was 12.66% in the ionic contrast media group and 3.13% in the nonionic contrast media group. Severe adverse drug reactions occurred in 0.22% of examinations in the ionic contrast media group and in 0.04% of examinations in the nonionic contrast media group. Thus, the use of nonionic contrast medium significantly reduces the frequency of severe and potentially life-threatening adverse drug reactions to contrast media.
一项规模最大的全国性对比临床研究评估了337647例接受高渗离子型造影剂或低渗非离子型造影剂的患者以及药物不良反应的发生率。离子型造影剂组药物不良反应的总体发生率为12.66%，非离子型造影剂组为3.13%。离子型造影剂组0.22%的检查出现严重药物不良反应，非离子型造影剂组为0.04%。因此，使用非离子型造影剂可显著降低造影剂严重及潜在危及生命的药物不良反应的发生频率。
