骨疗法对患有神经性厌食症的年轻女性胫骨骨质流失的影响。

The effects of bone therapy on tibial bone loss in young women with anorexia nervosa.

作者信息

Nakahara Toshihiro, Nagai Nobuatsu, Tanaka Muneki, Muranaga Tetsuro, Kojima Shinya, Nozoe Shin-ichi, Naruo Tetsuro

机构信息

Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan.

出版信息

Int J Eat Disord. 2006 Jan;39(1):20-6. doi: 10.1002/eat.20197.

DOI:10.1002/eat.20197

PMID:16231362

Abstract

OBJECTIVE

Osteoporosis is recognized as a common medical complication of anorexia nervosa (AN). The purpose of the current study was to investigate the recovery mechanism of osteoporosis in AN and the effect of medical treatment on the skeletal system.

METHOD

We conducted a randomized placebo-controlled study of the effects of etidronate and calcium and vitamin D on bone loss in 41 outpatients with the restricting type of AN (AN-R). We measured the tibial speed of sound (SOS) before and after 3 months of treatment.

RESULTS

The bone mineral density (BMD) of the tibial SOS change in both the etidronate group and the calcium and vitamin D Group was significantly greater (p < .001) than in the control group. Urine-N-telopeptide cross-links of type I collagen (NTx) before and after treatment decreased significantly (p < .01) in the etidronate group.

CONCLUSION

These findings suggest that both etidronate and calcium and vitamin D are equally efficacious for reversing the degree of osteoporosis in patients with AN.

摘要