Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Iowa Carver College of Medicine, E 426 GH, 200 Hawkins Drive, Iowa City, IA, 52242, USA,
Eat Weight Disord. 2013 Jun;18(2):229-31. doi: 10.1007/s40519-013-0034-y. Epub 2013 Apr 20.
Osteoporosis commonly occurs in patients with anorexia nervosa (AN) and is often irreversible even after weight restoration. We describe a 52-year-old woman with AN and severe osteoporosis, discovered after she sustained multiple fractures from a fall. She had low weight for most of her life, but was only formally diagnosed with AN 6 years prior to her presentation. She received therapy for her eating disorder and was able to restore weight, which led to a 4.1 % improvement in her bone density. We then treated her with teriparatide for 2 years, which lead to a further 21 % increase in bone density and she has had no recurrence of fractures. Since AN-associated osteoporosis is characterized by low bone formation, teriparatide may be a useful treatment option.
骨质疏松症在神经性厌食症（AN）患者中很常见，即使在体重恢复后也常常是不可逆转的。我们描述了一位 52 岁的女性患有 AN 和严重的骨质疏松症，她在跌倒后多处骨折后被发现。她一生中大部分时间体重都很低，但直到她出现症状前 6 年才被正式诊断为 AN。她接受了饮食失调症的治疗并恢复了体重，这使她的骨密度提高了 4.1%。随后，我们用特立帕肽治疗了她 2 年，骨密度又增加了 21%，她再也没有骨折复发。由于与 AN 相关的骨质疏松症的特征是骨形成减少，因此特立帕肽可能是一种有用的治疗选择。
