香豆素抗凝治疗管理中的药物遗传学：是前进的道路还是昂贵的弯路？
Pharmacogenetics in the management of coumarin anticoagulant therapy: the way forward or an expensive diversion?
作者信息
Greaves Mike
机构信息
School of Medicine, University of Aberdeen, Aberdeen, United Kingdom.
出版信息
PLoS Med. 2005 Oct;2(10):e342. doi: 10.1371/journal.pmed.0020342. Epub 2005 Oct 25.
Abstract
Greaves discusses a new study in that takes us closer to being able to adopt a pharmacogenetic approach to reduce bleeding risk from coumarin therapy.
摘要
格里夫斯讨论了一项新研究，该研究使我们更接近能够采用药物遗传学方法来降低香豆素治疗的出血风险。
相似文献
1
Pharmacogenetics in the management of coumarin anticoagulant therapy: the way forward or an expensive diversion?香豆素抗凝治疗管理中的药物遗传学：是前进的道路还是昂贵的弯路？
PLoS Med. 2005 Oct;2(10):e342. doi: 10.1371/journal.pmed.0020342. Epub 2005 Oct 25.
2
[Resistance to coumarin derivatives due to mutated vitamin-K enzyme].
Ned Tijdschr Geneeskd. 2009;153:A691.
3
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.香豆素类抗凝剂敏感型维生素K环氧化物还原酶复合物1（VKORC1）的定点诱变：高度保守氨基酸决定酶活性及对华法林抑制作用的结构要求的证据
Thromb Haemost. 2005 Oct;94(4):780-6. doi: 10.1160/TH05-02-0082.
4
Oral anticoagulants: Pharmacogenetics Relationship between genetic and non-genetic factors.
Blood Rev. 2008 May;22(3):127-40. doi: 10.1016/j.blre.2007.11.004. Epub 2008 Jan 30.
5
6
The pharmocogenomics of warfarin: closing in on personalized medicine.华法林的药物基因组学：迈向个性化医疗
Mol Interv. 2006 Aug;6(4):223-7. doi: 10.1124/mi.6.4.8.
7
The pharmacogenetics of coumarin therapy.香豆素疗法的药物遗传学
Pharmacogenomics. 2005 Jul;6(5):503-13. doi: 10.2217/14622416.6.5.503.
8
[Vitamin K epoxide reductase: Fresh blood for oral anticoagulant therapies].[维生素K环氧化物还原酶：口服抗凝治疗的新希望]
Rev Med Interne. 2006 Dec;27(12):979-82. doi: 10.1016/j.revmed.2006.09.004. Epub 2006 Oct 11.
9
Pharmacogenetics-based coumarin therapy.基于药物遗传学的香豆素疗法。
Hematology Am Soc Hematol Educ Program. 2006:467-73. doi: 10.1182/asheducation-2006.1.467.
10
[New insight in therapeutic anticoagulation by Coumarin derivatives].[香豆素衍生物在治疗性抗凝方面的新见解]
Hamostaseologie. 2008 Feb;28(1-2):44-50.
引用本文的文献
1
Synthesis, biological evaluation, pharmacological profiling, and molecular docking studies of 4-Aminocoumarin based phenyliodonium derivatives as potent therapeutic agents.基于4-氨基香豆素的苯基碘鎓衍生物作为有效治疗剂的合成、生物学评价、药理学分析及分子对接研究
Sci Rep. 2025 Jul 1;15(1):21762. doi: 10.1038/s41598-025-95078-8.
2
Coumarin-amino acid hybrids as promising anticancer agents: design, synthesis, docking studies and CK2 inhibition.香豆素-氨基酸杂化物作为有前景的抗癌剂：设计、合成、对接研究及CK2抑制作用
RSC Adv. 2024 Aug 6;14(34):24671-24686. doi: 10.1039/d4ra04226c. eCollection 2024 Aug 5.
3
Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach.具有抗血栓和抗血小板作用的天然酚类化合物：一种类似药物的方法。
Curr Med Chem. 2024;31(26):4138-4159. doi: 10.2174/0109298673268452231108061008.
4
Post-operative haemorrhage secondary to cinnamon use. A case report.肉桂使用继发的术后出血。一例病例报告。
Int J Surg Case Rep. 2022 Jun;95:107179. doi: 10.1016/j.ijscr.2022.107179. Epub 2022 May 10.
5
Exploration of Chromone-Based Thiosemicarbazone Derivatives: SC-XRD/DFT, Spectral (IR, UV-Vis) Characterization, and Quantum Chemical Analysis.基于色酮的硫代氨基脲衍生物的探索：单晶X射线衍射/密度泛函理论、光谱（红外、紫外可见）表征及量子化学分析
ACS Omega. 2020 Nov 10;5(46):30176-30188. doi: 10.1021/acsomega.0c04653. eCollection 2020 Nov 24.
6
Association between VKORC1 gene polymorphism and warfarin dose requirement and frequency of VKORC1 gene polymorphism in patients from Kerman province.VKORC1 基因多态性与华法林剂量需求及患者华法林基因多态性频率的相关性。
在伊朗克尔曼省的患者中。
Pharmacogenomics J. 2020 Aug;20(4):574-578. doi: 10.1038/s41397-019-0146-5. Epub 2020 Jan 6.
7
Synthesis and Characterization of Some New Coumarins with in Vitro Antitumor and Antioxidant Activity and High Protective Effects against DNA Damage.一些具有体外抗肿瘤、抗氧化活性及对DNA损伤有高度保护作用的新型香豆素的合成与表征
Molecules. 2016 Feb 22;21(2):249. doi: 10.3390/molecules21020249.
8
Identification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy.华法林治疗的伊朗患者中CYP2C9和VKORC1基因多态性的鉴定。
Int J Hematol Oncol Stem Cell Res. 2015 Oct 1;9(4):185-92.
9
Anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the South China Sea.南海红树林真菌代谢产物中分离得到的海洋产物的抗癌作用及构效关系分析。
Mar Drugs. 2010 Apr 1;8(4):1094-105. doi: 10.3390/md8041094.
本文引用的文献
1
A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk.维生素K环氧化物还原酶复合体亚单位1（VKORC1）基因中的C1173T二态性决定了香豆素敏感性和出血风险。
PLoS Med. 2005 Oct;2(10):e312. doi: 10.1371/journal.pmed.0020312. Epub 2005 Oct 11.
2
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.维生素K环氧化物还原酶复合体亚单位1（VKORC1）单倍型对转录调控及华法林剂量的影响。
N Engl J Med. 2005 Jun 2;352(22):2285-93. doi: 10.1056/NEJMoa044503.
3
The influence of ethnicity on warfarin dosage requirement.
Ann Pharmacother. 2005 Jun;39(6):1008-12. doi: 10.1345/aph.1E566. Epub 2005 Apr 26.
4
Polymorphisms in factor II and factor VII genes modulate oral anticoagulation with warfarin.凝血因子II和凝血因子VII基因的多态性可调节华法林的口服抗凝作用。
Haematologica. 2004 Dec;89(12):1510-6.
5
Identification of the gene for vitamin K epoxide reductase.维生素K环氧化物还原酶基因的鉴定。
Nature. 2004 Feb 5;427(6974):541-4. doi: 10.1038/nature02254.
6
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.华法林治疗期间CYP2C9基因变异与抗凝相关结局的关联。
JAMA. 2002 Apr 3;287(13):1690-8. doi: 10.1001/jama.287.13.1690.
7
8
Vitamin K intake and sensitivity to warfarin in patients consuming regular diets.正常饮食患者的维生素K摄入量与对华法林的敏感性
Thromb Haemost. 1999 Mar;81(3):396-9.
9
Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin.
Br J Haematol. 1998 Nov;103(2):422-4. doi: 10.1046/j.1365-2141.1998.00988.x.
10
Factors determining the maintenance dose of warfarin in Chinese patients.决定中国患者华法林维持剂量的因素。
QJM. 1996 Feb;89(2):127-35. doi: 10.1093/qjmed/89.2.127.
Zotero 插件