Putnam Nicole M, Hofer Heidi J, Doble Nathan, Chen Li, Carroll Joseph, Williams David R
The Institute of Optics, University of Rochester, Rochester, NY, USA.
J Vis. 2005 Aug 17;5(7):632-9. doi: 10.1167/5.7.3.
High-resolution retinal imaging with adaptive optics was used to record the position of a light stimulus on the cone mosaic, with an error at least five times smaller than the diameter of the smallest foveal cones. We discuss the factors that limit the accuracy with which absolute retinal position can be determined. In five subjects, the standard deviation of fixation positions measured in discrete trials ranged from 2.1 to 6.3 arcmin, with an average of 3.4 arcmin (about 17 microm), in agreement with previous studies (R. W. Ditchburn, 1973; R. M. Steinman, G. M. Haddad, A. A. Skavenski, & D. Wyman, 1973). The center of fixation, based on the mean retinal position for each of three subjects, was displaced from the location of highest foveal cone density by an average of about 10 arcmin (about 50 microm), indicating that cone density alone does not drive the location on the retina selected for fixation. This method can be used in psychophysical studies or medical applications requiring submicron registration of stimuli with respect to the retina or in delivering light to retinal features as small as single cells.
采用自适应光学的高分辨率视网膜成像技术记录了光刺激在视锥镶嵌上的位置，其误差至少比最小中央凹视锥直径小五倍。我们讨论了限制确定视网膜绝对位置准确性的因素。在五名受试者中，离散试验中测量的注视位置标准差在2.1至6.3角分之间，平均为3.4角分（约17微米），与先前的研究结果一致（R. W. 迪奇伯恩，1973年；R. M. 斯坦曼、G. M. 哈达德、A. A. 斯卡文斯基和D. 怀曼，1973年）。基于三名受试者各自的平均视网膜位置确定的注视中心，与中央凹视锥密度最高的位置平均偏移约10角分（约50微米），这表明仅视锥密度并不能决定所选注视视网膜位置。该方法可用于心理物理学研究或需要将刺激与视网膜进行亚微米配准的医学应用，或用于向单个细胞那么小的视网膜特征传递光。
