Buxton R S, Magee A I
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK.
Semin Cell Biol. 1992 Jun;3(3):157-67. doi: 10.1016/s1043-4682(10)80012-1.
The cadherin superfamily of cell-cell adhesion molecules is now known to include proteins of the desmosome as well as of the adherens type of junction. The desmosomal cadherins consist of two families of proteins, the desmocollins and the desmogleins, both of which are represented by different isoforms which are differentially expressed in epidermis. The desmocollins are quite similar to the classic cadherins in overall structure, but with alternatively spliced variants; the desmogleins have extra cytoplasmic sequences added onto the basic cadherin structure. The cytoplasmic domains are specialized for binding to 'mediator' proteins, such as plakoglobin, which interconnect to the intermediate filament system rather than the actin filaments as do the classic cadherins.
细胞间黏附分子的钙黏蛋白超家族现在已知包括桥粒蛋白以及黏着连接类型的蛋白。桥粒钙黏蛋白由两个蛋白家族组成，即桥粒芯蛋白和桥粒芯胶蛋白，两者都有不同的亚型，这些亚型在表皮中差异表达。桥粒芯蛋白在整体结构上与经典钙黏蛋白非常相似，但有可变剪接变体；桥粒芯胶蛋白在基本钙黏蛋白结构上添加了额外的胞质序列。胞质结构域专门用于与“介导”蛋白结合，如桥粒斑珠蛋白，它与中间丝系统相连，而不像经典钙黏蛋白那样与肌动蛋白丝相连。
