Caddy G R, Kirby J, Kirk S J, Allen M J, Moorehead R J, Tham T C
Department of Gastroenterology, Ulster Community & Hospitals Trust, Dundonald, Belfast.
Ulster Med J. 2005 Sep;74(2):108-12.
There is little data on the natural history of asymptomatic bile duct stones and hence there is uncertainty on the management of asymptomatic bile duct stones discovered incidentally at the time of laparoscopic cholecystectomy. We retrospectively reviewed a group of patients who had previously underwent laparoscopic cholecystectomy, but who did not have a pre-operative suspicion of intra-ductal stones, to determine if any biliary complications had subsequently developed. A group of patients who had no pre-operative suspicion of intra-ductal stones, but routinely underwent intraoperative cholangiogram (IOC) at time of cholecystectomy, served as the control group.
A telephone questionnaire was completed by each patient's family practitioner in 59 of 79 (75%) patients who underwent laparoscopic cholecystectomy. In the remaining 20 patients additional information was obtained from hospital records and from the central services agency (CSA). These patients had no pre-operative suspicion of bile duct stones and therefore did not undergo an IOC or ERCP. The control group (73 patients) had no pre-operative suspicion of bile duct stones but had a routine IOC performed to define the biliary anatomy.
59 patients were followed up for an average of 57 months (range 30-78 months) after laparoscopic cholecystectomy. None of these patients developed pancreatitis, jaundice, deranged liver function tests (LFT's), or required ERCP or other biliary intervention. In the additional 20 patients where no information was available from the family practitioner, 11 patients had follow up appointments with no documentation of biliary complications or abnormal LFT's. 19 of 20 patients were traceable through the CSA and were all alive. Only 1 patient was untraceable and therefore unknown if biliary complications had developed. In the control group, 4 of 73 (6%) patients had intraductal stones detected and extracted. Thus the prevalence of asymptomatic bile duct stones during the time of cholecystectomy in our population was 6%.
Asymptomatic bile duct stones discovered at the time of cholecystectomy do not appear to cause any biliary complications over a 5-year follow up. Incidental bile duct stones found in patients undergoing laparoscopic cholecystectomy may not need to be removed.
关于无症状胆管结石自然病史的数据很少,因此对于在腹腔镜胆囊切除术时偶然发现的无症状胆管结石的处理存在不确定性。我们回顾性研究了一组先前接受过腹腔镜胆囊切除术但术前未怀疑有胆管结石的患者,以确定随后是否发生了任何胆道并发症。一组术前未怀疑有胆管结石但在胆囊切除术时常规进行术中胆管造影(IOC)的患者作为对照组。
79例接受腹腔镜胆囊切除术的患者中,59例(75%)患者的家庭医生完成了一份电话调查问卷。其余20例患者从医院记录和中央服务机构(CSA)获得了额外信息。这些患者术前未怀疑有胆管结石,因此未进行IOC或内镜逆行胰胆管造影(ERCP)。对照组(73例患者)术前未怀疑有胆管结石,但进行了常规IOC以明确胆道解剖结构。
59例患者在腹腔镜胆囊切除术后平均随访57个月(范围30 - 78个月)。这些患者均未发生胰腺炎、黄疸、肝功能检查异常,也未需要ERCP或其他胆道干预。在另外20例家庭医生未提供信息的患者中,11例患者进行了随访,没有胆道并发症或肝功能检查异常的记录。20例患者中有19例可通过CSA追踪到,且均存活。只有1例患者无法追踪,因此不清楚是否发生了胆道并发症。在对照组中,73例患者中有4例(6%)检测到并取出了胆管内结石。因此,在我们的研究人群中,胆囊切除术时无症状胆管结石的患病率为6%。
胆囊切除术时发现的无症状胆管结石在5年随访期间似乎不会引起任何胆道并发症。在接受腹腔镜胆囊切除术的患者中偶然发现的胆管结石可能无需取出。