Thomsen Reimar W, Johnsen Søren P, Olesen Anne V, Mortensen Jens T, Bøggild Henrik, Olsen Jørn, Sørensen Henrik T
Department of Clinical Epidemiology, Aarhus University Hospital, Stengade 10 2nd floor, DK-9000 Aalborg, Denmark.
Br J Clin Pharmacol. 2005 Nov;60(5):534-42. doi: 10.1111/j.1365-2125.2005.02494.x.
Socioeconomic inequalities in statin use are a public health concern but they may also confound observational studies of statins' effectiveness. We conducted a population-based cross-sectional study in Denmark to examine the association between socioeconomic status (SES) and statin use.
We obtained data on socioeconomic status of all persons in North Jutland County, Denmark, between 1995 and 1999 from the Prevention Registry at Statistics Denmark. Data on filled statin prescriptions were identified through the County Prescription Database. We compared the 1-year prevalence proportions of statin use for different socioeconomic groups, adjusted for age and urbanization. Separate analyses were done for patients with a history of cardiovascular disease as recorded in the County Hospital Discharge Registry.
Among men with cardiovascular disease, statin use in 1995 was higher in those with the highest socioeconomic status (adjusted relative prevalence proportion (RPP) among top managers 1.86, 95% CI: 1.17-2.96), and lower among retired men (RPP (95% CI) 0.63 [0.43-0.93] in old-age pensioners, and 0.66 [0.45-0.98] in the early retired), when compared with basic-level workers. The socioeconomic differences in statin use among men decreased in magnitude over time but remained throughout the study period. We found no clear social gradient in statin use among women.
Even in a health care system that claims to ensure a high degree of equity in medical care, we found clear indications of a socioeconomic gradient in statin use among men in the years after the launching of these drugs.
他汀类药物使用中的社会经济不平等是一个公共卫生问题,但它们也可能混淆他汀类药物有效性的观察性研究。我们在丹麦进行了一项基于人群的横断面研究,以检验社会经济地位(SES)与他汀类药物使用之间的关联。
我们从丹麦统计局的预防登记处获得了1995年至1999年丹麦北日德兰郡所有人的社会经济地位数据。通过郡处方数据库确定了他汀类药物处方的填充数据。我们比较了不同社会经济群体使用他汀类药物的1年患病率,并对年龄和城市化进行了调整。对郡医院出院登记处记录的有心血管疾病史的患者进行了单独分析。
在患有心血管疾病的男性中,1995年社会经济地位最高的人群中他汀类药物的使用率更高(高层管理人员的调整后相对患病率比例(RPP)为1.86,95%置信区间:1.17 - 2.96),与基层工人相比,退休男性的使用率较低(养老金领取者的RPP(95%置信区间)为0.63 [0.43 - 0.93],提前退休者为0.66 [0.45 - 0.98])。男性中他汀类药物使用的社会经济差异随着时间的推移幅度减小,但在整个研究期间仍然存在。我们在女性中未发现他汀类药物使用的明显社会梯度。
即使在一个声称确保医疗保健高度公平的医疗系统中,我们也发现了在这些药物推出后的几年里,男性使用他汀类药物存在社会经济梯度的明确迹象。