Takáts Zoltán, Wiseman Justin M, Cooks R Graham
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
J Mass Spectrom. 2005 Oct;40(10):1261-75. doi: 10.1002/jms.922.
Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to high-throughput analyses are presented. Evidence is provided for both a heterogeneous charge-transfer mechanism and a droplet pick-up mechanism of ionization. The speed, lack of the need for sample preparation, selectivity, and sensitivity of DESI are all demonstrated and discussed. Instrumentation is also discussed. Forensic applications as well as emerging areas of application including tissue imaging are given emphasis.
总结了常压敞开式离子源质谱（DESI）的分析特性。展示了其在小分子和大分子、原位分析以及高通量分析中的应用实例。为非均相电荷转移机制和液滴拾取电离机制提供了证据。论证并讨论了DESI的速度、无需样品制备、选择性和灵敏度。还讨论了仪器设备。重点介绍了法医应用以及包括组织成像在内的新兴应用领域。
