Sibaï K, Eggimann P
Clinique médicale 2, Département de médecine interne HUG, 1211 Genève.
Rev Med Suisse. 2005 Sep 14;1(32):2106, 2108-10, 2112-5.
Alcoholic ketoacidosis is an often overlooked disorder, which affects chronic ethanol abusers who have usually had a binge culminating in severe vomiting with resulting hypovolemia, acute starvation and then a beta-hydroxybutyrate dominated ketoacidosis (due to the conjonction of enhanced Glucagon/Insuline and NADH/NAD ratios). Although the pathophysiology is complex, the syndrome is quickly reversible with the administration of saline and glucose solutions along with the correction of electrolyte disturbances, often unmasked during the treatment. Insuline and bicarbonates are not indicated. The prognosis, which is excellent, depends mainly on the coexisting acute disorders, which should be purchased and treated appropriately.
酒精性酮症酸中毒是一种常被忽视的疾病，它影响慢性乙醇滥用者，这些人通常有一次狂欢，最终导致严重呕吐，进而出现血容量不足、急性饥饿，随后是β-羟丁酸为主的酮症酸中毒（由于胰高血糖素/胰岛素和NADH/NAD比值升高共同作用）。尽管病理生理过程复杂，但通过给予生理盐水和葡萄糖溶液以及纠正电解质紊乱，该综合征通常可迅速逆转，而电解质紊乱常在治疗过程中被发现。胰岛素和碳酸氢盐并无必要使用。预后良好，主要取决于并存的急性疾病，应对这些疾病进行识别并适当治疗。
