Caspar C B, Risti B, Iten P X, Jost R, Russi E W, Speich R
Departement für Innere Medizin, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1993 Oct 16;123(41):1929-34.
Alcoholic ketoacidosis (AKA) is an important and probably underdiagnosed differential diagnosis for metabolic acidosis with an increased anion gap. It occurs in patients with prolonged ethanol intake. After a brief period of starvation induced by alcoholic gastritis patients typically present with vomiting, abdominal pain and Kussmaul breathing. Routine testing for urine or serum ketones with ketostix may be negative, since they do not detect beta-hydroxybutyrate and this is characteristically elevated in AKA. We present three cases of AKA and discuss diagnosis, pathophysiology and management of this disorder.
酒精性酮症酸中毒(AKA)是阴离子间隙增加的代谢性酸中毒的一种重要且可能未被充分诊断的鉴别诊断。它发生在长期摄入乙醇的患者中。在酒精性胃炎引起的短暂饥饿期后,患者通常会出现呕吐、腹痛和库斯莫尔呼吸。用尿酮试纸对尿液或血清酮进行常规检测可能为阴性,因为它们检测不到β-羟丁酸,而在AKA中β-羟丁酸通常会升高。我们报告三例AKA病例,并讨论这种疾病的诊断、病理生理学和管理。