Klintrup Kai, Mäkinen Johanna M, Kauppila Saila, Väre Päivi O, Melkko Jukka, Tuominen Hannu, Tuppurainen Karoliina, Mäkelä Jyrki, Karttunen Tuomo J, Mäkinen Markus J
Department of Surgery, Oulu University Hospital, Oulu, Finland.
Eur J Cancer. 2005 Nov;41(17):2645-54. doi: 10.1016/j.ejca.2005.07.017. Epub 2005 Oct 18.
Previous work has indicated that quantification of inflammatory cell reaction is of prognostic value in colorectal cancer. We evaluated the prognostic significance of inflammatory cell reaction patterns in colorectal cancer and developed a grading method which could be used in the routine assessment of tumours.
The intensity of overall inflammatory cell reaction, numbers of neutrophilic and eosinophilic granulocytes, lymphoid cells and macrophages in both the central region and the invasive margin were estimated in 386 colorectal cancer patients. Prognostic significance was analysed by uni- and multivariate analysis.
Our method for classification of inflammatory reaction was reliable. High-grade inflammation at the invasive margin in Dukes' stage A and B cancers (pT1-2N0 and pT3N0, respectively) was associated with better 5-year-survival (87.6%) than low-grade inflammation (47.0%).
Inflammatory cell response at the invasive border is a relevant prognostic indicator and could be easily incorporated into the routine evaluation of histopathological specimens.
以往研究表明，炎症细胞反应的量化在结直肠癌中具有预后价值。我们评估了结直肠癌中炎症细胞反应模式的预后意义，并开发了一种可用于肿瘤常规评估的分级方法。
对386例结直肠癌患者的中央区域和浸润边缘的总体炎症细胞反应强度、中性粒细胞、嗜酸性粒细胞、淋巴细胞和巨噬细胞数量进行了评估。通过单因素和多因素分析来分析预后意义。
我们的炎症反应分类方法可靠。在Dukes分期A和B期癌症（分别为pT1-2N0和pT3N0）中，浸润边缘的高级别炎症与较好的5年生存率（87.6%）相关，而低级别炎症的5年生存率为47.0%。
浸润边缘的炎症细胞反应是一个相关的预后指标，并且可以很容易地纳入组织病理学标本的常规评估中。
