Roxburgh Campbell S D, Salmond Jonathan M, Horgan Paul G, Oien Karin A, McMillan Donald C
University Department of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
Eur J Cancer. 2009 Aug;45(12):2138-45. doi: 10.1016/j.ejca.2009.04.011. Epub 2009 May 4.
A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer.
Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass' and Klintrup's criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time.
Low-grade inflammatory infiltrate assessed using Klintrup's criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n=179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin.
Assessment of inflammatory infiltrate using Klintrup's criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth.
众所周知，明显的肿瘤炎性浸润在结直肠癌中预示着良好的预后。克林特鲁普及其同事报告了对浸润边缘炎症反应的结构化评估，分为低度或高度。本研究的目的是检验肿瘤炎性浸润在无淋巴结转移结直肠癌中的预后价值。
200例患者在1997年至2004年间接受了无淋巴结转移结直肠癌手术。标本根据贾斯和克林特鲁普的肿瘤周围浸润标准进行评分。病理数据取自当时的报告。
使用克林特鲁普标准评估的低度炎性浸润是无淋巴结转移疾病的独立预后因素。在彼得森指数低风险的患者（n = 179）中，低度浸润使癌症死亡风险增加两倍。低度浸润与T分期增加和浸润边缘有关。
使用克林特鲁普标准评估炎性浸润可为无淋巴结转移结直肠癌提供独立的预后信息。高度的局部炎症反应可能代表有效的宿主免疫反应，阻碍肿瘤生长。
