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阴道上皮细胞抗白色念珠菌活性与预防有症状的阴道念珠菌病相关。

Vaginal epithelial cell anti-Candida albicans activity is associated with protection against symptomatic vaginal candidiasis.

作者信息

Barousse Melissa M, Espinosa Terri, Dunlap Kathleen, Fidel Paul L

机构信息

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

出版信息

Infect Immun. 2005 Nov;73(11):7765-7. doi: 10.1128/IAI.73.11.7765-7767.2005.

DOI:10.1128/IAI.73.11.7765-7767.2005
PMID:16239581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1273905/
Abstract

Vaginal epithelial cell (VEC) anti-Candida albicans activity, despite being measured in vitro, is considered an innate host defense mechanism. This was supported further by the fact that women protected from symptomatic infection following a live intravaginal Candida challenge had increased VEC anti-Candida activity compared to those who acquired a symptomatic infection.

摘要

阴道上皮细胞（VEC）抗白色念珠菌活性尽管是在体外测量的，但被认为是一种先天性宿主防御机制。以下事实进一步支持了这一点：在经阴道给予活的白色念珠菌进行挑战后，未发生症状性感染的女性相比发生症状性感染的女性，其VEC抗白色念珠菌活性有所增加。

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本文引用的文献

1
Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells.口腔和阴道上皮细胞的抗念珠菌活性对酸不稳定，且不需要活的上皮细胞。
Oral Microbiol Immunol. 2005 Aug;20(4):199-205. doi: 10.1111/j.1399-302X.2005.00212.x.
2
Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils.白色念珠菌中SSK1应答调节基因的缺失有助于增强人类多形核中性粒细胞的杀伤作用。
Infect Immun. 2005 Feb;73(2):865-71. doi: 10.1128/IAI.73.2.865-871.2005.
3
History and new insights into host defense against vaginal candidiasis.宿主抗阴道念珠菌病防御的历史与新见解
Trends Microbiol. 2004 May;12(5):220-7. doi: 10.1016/j.tim.2004.03.006.
4
An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis.在人类中进行的阴道内白色念珠菌活菌激发试验为外阴阴道念珠菌病的免疫发病机制带来了新的假说。
Infect Immun. 2004 May;72(5):2939-46. doi: 10.1128/IAI.72.5.2939-2946.2004.
5
Vaginal yeast colonisation, prevalence of vaginitis, and associated local immunity in adolescents.青少年阴道酵母菌定植、阴道炎患病率及相关局部免疫
Sex Transm Infect. 2004 Feb;80(1):48-53. doi: 10.1136/sti.2002.003855.
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Infect Immun. 2002 Dec;70(12):7081-8. doi: 10.1128/IAI.70.12.7081-7088.2002.
7
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Differential susceptibility of two species of macaques to experimental vaginal candidiasis.两种猕猴对实验性阴道念珠菌病的易感性差异
J Infect Dis. 1999 Sep;180(3):802-10. doi: 10.1086/314964.