Khan Maria, Ahmed Jawad, Gul Amina, Ikram Aamer, Lalani Farida Khurram
Department of Microbiology, Armed Forces Institute of Pathology, National University of Management Sciences, CMH Rawalpindi, Rawalpindi, Pakistan.
Department of Microbiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Infect Drug Resist. 2018 Mar 28;11:447-456. doi: 10.2147/IDR.S153116. eCollection 2018.
Vulvovaginal candidiasis (VVC) is considered as a pervasive gynecological problem among women worldwide. Owing to this fact, in the current study, we aimed at assessing the prevalence rate of spp. causing VVC in symptomatic pregnant women and their antifungal susceptibility pattern.
This study was carried out in the tertiary care hospitals of Peshawar during the period of July 1, 2016 to December 31, 2016. The study group included 450 pregnant women in the age group of 17-44 years with symptoms of excessive vaginal discharge, pain and pruritis. In all, 108 pregnant women were culture positive for . Antimicrobial susceptibility testing (AST) was conducted on specimens against various azoles and polyene F group of antifungals.
Out of 108 spp. isolated from vaginal swabs, there were 45 (41.7%) , 18 (16.7%) , 18 (16.7%) , 16 (14.8%) and 11 (10.2%) . According to age distribution, 27 years was the mean age. Pregnancy trimester distribution among patients was as follows: 21 (19.4%) patients were in their first trimester, 65 (60.2%) patients were in their second trimester and 22 (20.4%) patients were in the third trimester. Susceptibility of fluconazole was determined as follows: 33.3% of the isolates were sensitive, 4.6% were susceptible dose dependent (SDD) and 62% were resistant. Susceptibility of spp. with respect to nystatin in patients with VVC was as follows: 25% were sensitive, 16.7% were SDD and 58.3% were resistant. Susceptibility of clotrimazole was analyzed, and it was sensitive in 21.3% of patients, SDD in 19.4% of patients and resistant in 59.3% of patients. Voriconazole susceptibility was recorded to be sensitive in 85.2% of patients, SDD in 4.6% of patients and resistant in 10.2% of patients suffering from VVC. Susceptibility results for itraconazole in patients with VVC were as follows: 42.6% of patients were sensitive, 16.7% of patients were SDD, and 40.7% of patients were resistant.
In this study, frequency of VVC was noted to be high in the second trimester of pregnancy, with the highest frequency of isolated, followed by and . Antifungal susceptibility testing revealed that fluconazole was exceedingly resistant against species (62%), followed by clotrimazole (59.3%) and nystatin (58.3%). On the contrary, voriconazole had the highest antimicrobial activity against species (85.2%).
外阴阴道假丝酵母菌病（VVC）被认为是全球女性中普遍存在的妇科问题。鉴于此，在本研究中，我们旨在评估有症状的孕妇中引起VVC的假丝酵母菌属物种的流行率及其抗真菌药敏模式。
本研究于2016年7月1日至2016年12月31日在白沙瓦的三级护理医院进行。研究组包括450名年龄在17 - 44岁之间、有阴道分泌物过多、疼痛和瘙痒症状的孕妇。总共108名孕妇的培养结果呈阳性。对标本进行了针对各种唑类和多烯类F组抗真菌药物的抗菌药敏试验（AST）。
从阴道拭子中分离出的108株假丝酵母菌属物种中，有45株（41.7%）白色假丝酵母菌，18株（16.7%）光滑假丝酵母菌，18株（16.7%）热带假丝酵母菌，16株（14.8%）近平滑假丝酵母菌和11株（10.2%）其他假丝酵母菌。根据年龄分布，平均年龄为27岁。患者的妊娠 trimester分布如下：21名（19.4%）患者处于妊娠早期，65名（60.2%）患者处于妊娠中期，22名（20.4%）患者处于妊娠晚期。氟康唑的药敏情况如下：分离出的白色假丝酵母菌中有33.3%敏感，4.6%剂量依赖敏感（SDD），62%耐药。VVC患者中近平滑假丝酵母菌对制霉菌素的药敏情况如下：25%敏感，16.7% SDD，58.3%耐药。分析了克霉唑的药敏情况，21.3%的患者敏感，19.4%的患者SDD，59.3%的患者耐药。伏立康唑的药敏情况显示，85.2%的VVC患者敏感，4.
