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用重组肺炎链球菌神经氨酸酶NanA进行免疫可保护栗鼠免受鼻咽部定植。

Immunization with recombinant Streptococcus pneumoniae neuraminidase NanA protects chinchillas against nasopharyngeal colonization.

作者信息

Tong H H, Li D, Chen S, Long J P, DeMaria T F

机构信息

Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett Hall, 456 W. 10th Ave., Columbus, OH 43210, USA.

出版信息

Infect Immun. 2005 Nov;73(11):7775-8. doi: 10.1128/IAI.73.11.7775-7778.2005.

DOI:10.1128/IAI.73.11.7775-7778.2005
PMID:16239584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1273864/
Abstract

Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.

摘要

用重组肺炎链球菌神经氨酸酶NanA（rNanA）进行免疫接种，可使栗鼠模型中的肺炎球菌定植显著减少。细菌从鼻咽部清除的时间比对照组提前1周。我们的数据表明，rNanA可提供针对肺炎球菌鼻咽部定植的保护作用。

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A pain in the ear: what has the 7-valent conjugated pneumococcal vaccine done to reduce the incidence of acute otitis media?耳部疼痛：7价结合肺炎球菌疫苗在降低急性中耳炎发病率方面起到了什么作用？
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Tissue-specific contributions of pneumococcal virulence factors to pathogenesis.肺炎球菌毒力因子对发病机制的组织特异性作用。
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Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway.在体内与肺炎链球菌结合并保护气道的宿主蛋白的相变去唾液酸化作用。
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Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.抗体在小鼠肺炎链球菌定植模型中清除细菌方面的作用有限。
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