Gallie B L, Dunn J M, Hamel P A, Muncaster M, Cohen B L, Phillips R A
Department of Ophthalmology, University of Toronto, Canada.
Eye (Lond). 1992;6 ( Pt 2):226-31. doi: 10.1038/eye.1992.44.
The causes of retinoblastoma (RB) can now be described with considerable accuracy, although many details are still unclear. Understanding the genetic changes leading to RB has provided an awareness of general mechanisms of cancer development and progression, previously only suspected. From the basic understanding have come new diagnostic technologies that are now ready to be applied directly to RB patients and their families, and a rational approach, based on this understanding, will help us to develop new therapies that avoid the severe complications of conventional treatment.
视网膜母细胞瘤（RB）的病因目前已能较为准确地描述，尽管许多细节仍不清楚。对导致RB的基因变化的了解，让人们认识到了癌症发生和发展的一般机制，而这些机制此前只是被怀疑存在。基于这一基本认识，现已出现了可直接应用于RB患者及其家属的新诊断技术，并且基于这一认识的合理方法将有助于我们开发新的治疗方法，避免传统治疗带来的严重并发症。
