Shpitzer Thomas, Keller Nathan, Wolf Michael, Goldschmied-Reouven Anna, Bahar Gideon, Bahar Irit, Kronenberg Jona, Feinmesser Raphael, Talmi Yoav P
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikvah, Israel.
Ann Otol Rhinol Laryngol. 2005 Sep;114(9):695-8. doi: 10.1177/000348940511400907.
Rhino-orbito-cerebral mucormycosis (ROCM) is an uncommon, potentially lethal infection that occurs mostly in immunocompromised hosts. The seasonal occurrence of ROCM was studied in two of Israel's largest medical centers.
A total of 36 patients were seen during a 25-year period in this retrospective bi-institutional cohort study. Meteorologic data were obtained and analyzed for a possible linkage of infection with precipitation and temperature.
Twenty-one of the 36 patients (58%) presented between the months of August and October, and 27 patients (75%) presented between the months of August and December. A peak incidence of ROCM was noted in the month of September (13/36 patients; 36%). No association was noted between meteorologic conditions and the incidence of ROCM infection.
A consistent seasonal peak was observed in ROCM. Heightened awareness is important for early recognition and treatment of this disease.
鼻眶脑毛霉菌病（ROCM）是一种罕见的、潜在致命的感染，主要发生在免疫功能低下的宿主中。在以色列两个最大的医疗中心对ROCM的季节性发病情况进行了研究。
在这项回顾性双机构队列研究中，25年间共观察了36例患者。获取并分析气象数据，以探讨感染与降水和温度之间可能存在的联系。
36例患者中有21例（58%）在8月至10月就诊，27例（75%）在8月至12月就诊。ROCM的发病高峰出现在9月（13/36例患者；36%）。未发现气象条件与ROCM感染发病率之间存在关联。
观察到ROCM存在一致的季节性高峰。提高认识对于该疾病的早期识别和治疗很重要。
