Sakamoto K, Watanabe M, De La Cruz C, Honda H, Ise H, Mitsui K, Namiki K, Mikami Y, Moriya T, Sasano H
Department of Pathology, Tohoku University Hospital, Sendai, Japan.
Histopathology. 2005 Nov;47(5):479-84. doi: 10.1111/j.1365-2559.2005.02241.x.
Invasive micropapillary carcinoma (IMPC) is associated with frequent lymph node metastasis and adverse clinical outcome. IMPC has been reported in breast, urinary bladder, ureter, lung and parotid gland but not in colon. We present the clinicopathological features of three cases of primary IMPC of the colon with a review of the literature.
The patients (one man and two women) were 53, 67 and 68 years old, respectively. The size of the tumour ranged from 20 to 100 mm in diameter. Histologically, all cases were composed predominantly of papillary tumour cell clusters with spaces in a background of fine fibrocollagenous stroma. One of the tumours (case 1) was nearly completely composed of IMPC, but the other two were associated with foci of adenocarcinoma and concurrent mucinous carcinoma, respectively. MUC1 was positive in all cases, suggestive of reverse cell orientation which is responsible for its unique histological features.
We report three cases of primary IMPC of the colon. Its clinical significance remains undetermined but the presence of this component may represent a poor prognostic factor.
浸润性微乳头状癌（IMPC）常伴有淋巴结转移及不良临床预后。IMPC已在乳腺、膀胱、输尿管、肺及腮腺中被报道，但未见有在结肠中发生的报道。我们报告3例原发性结肠IMPC的临床病理特征，并复习相关文献。
患者分别为1名男性和2名女性，年龄分别为53岁、67岁和68岁。肿瘤直径为20至100mm。组织学上，所有病例均以乳头状肿瘤细胞簇为主，在纤细的纤维胶原性间质背景中有间隙。其中1例肿瘤（病例1）几乎完全由IMPC构成，但另外2例分别伴有腺癌灶和黏液腺癌。所有病例MUC1均呈阳性，提示细胞反向排列，这是其独特组织学特征的原因。
我们报告3例原发性结肠IMPC。其临床意义尚不确定，但该成分的存在可能提示预后不良。
