New attachment and tissue regeneration.

In periodontology, the possibility of stimulating new connective tissue attachment to previously diseased root surfaces, and the regeneration of the supporting periodontal tissues destroyed by periodontitis have been under study for some years. This paper reviews the different experimental methods used to prepare root surfaces for optimal regeneration and attachment of periodontal tissues. The mechanisms of blood clot formation, adhesion to the root surface and wound maturation are considered, as are the future needs for research in this subject.