Regeneration and repair after biologic treatment of root surfaces in monkeys.

The healing of a new attachment procedure was evaluated in monkeys. Standard pedicle wounds similar to reverse bevel flaps were made in previously created periodontal pockets. The diseased root surfaces were treated with sodium deoxycholate (2%) and human plasma fraction Cohn IV (5%), applied to experimental sites for 1 minute each. Control surfaces were similarly treated with phosphate buffered physiological saline. The healing from the first to the 21st day was described (1) clinically, (2) histologically, (3) by rupture strength, and (4) by collagen production assays. All control sites healed with a dentogingival junction comprised only of junctional epithelium. Most experimental sites healed by means of junctional epithelium and some connective tissue new attachment at the apical extent of the wounds.