Wirthlin M R, Hancock E B, Gaugler R W
J Periodontol. 1981 Dec;52(12):729-35. doi: 10.1902/jop.1981.52.12.729.
The healing of a new attachment procedure was evaluated in monkeys. Standard pedicle wounds similar to reverse bevel flaps were made in previously created periodontal pockets. The diseased root surfaces were treated with sodium deoxycholate (2%) and human plasma fraction Cohn IV (5%), applied to experimental sites for 1 minute each. Control surfaces were similarly treated with phosphate buffered physiological saline. The healing from the first to the 21st day was described (1) clinically, (2) histologically, (3) by rupture strength, and (4) by collagen production assays. All control sites healed with a dentogingival junction comprised only of junctional epithelium. Most experimental sites healed by means of junctional epithelium and some connective tissue new attachment at the apical extent of the wounds.
在猴子身上评估了一种新附着程序的愈合情况。在先前形成的牙周袋中制作类似于反斜面瓣的标准蒂部伤口。用脱氧胆酸钠（2%）和人血浆组分Cohn IV（5%）处理患病的牙根表面，分别在实验部位涂抹1分钟。对照表面用磷酸盐缓冲生理盐水进行类似处理。描述了从第1天到第21天的愈合情况，包括：（1）临床观察；（2）组织学观察；（3）通过抗张强度评估；（4）通过胶原蛋白生成测定评估。所有对照部位愈合后，龈牙结合部仅由结合上皮组成。大多数实验部位通过结合上皮和伤口顶端部分的一些结缔组织新附着实现愈合。
