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丙泊酚诱导的癫痫样现象。

Propofol-induced seizure-like phenomena.

作者信息

Hickey Kenneth S, Martin David F, Chuidian Francis X

机构信息

Department of Emergency Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.

出版信息

J Emerg Med. 2005 Nov;29(4):447-9. doi: 10.1016/j.jemermed.2005.05.009.

DOI:10.1016/j.jemermed.2005.05.009
PMID:16243205
Abstract

Procedural sedation is a common practice in Emergency Medicine. Propofol has supplanted benzodiazepines in many centers as the drug of choice for procedural sedation. This article reports a case of seizure-like activity in an elderly man undergoing procedural sedation for a fracture reduction. The seizure-like activity was attributed to propofol. A review of the literature is discussed. When using propofol for sedation one should be aware of the risk of seizure-like activity.

摘要

程序性镇静是急诊医学中的常见操作。在许多中心,丙泊酚已取代苯二氮䓬类药物,成为程序性镇静的首选药物。本文报告了一例老年男性在接受骨折复位程序性镇静时出现类似癫痫发作活动的病例。这种类似癫痫发作的活动被归因于丙泊酚。文中还讨论了文献综述。使用丙泊酚进行镇静时,应意识到存在类似癫痫发作活动的风险。

相似文献

1
Propofol-induced seizure-like phenomena.丙泊酚诱导的癫痫样现象。
J Emerg Med. 2005 Nov;29(4):447-9. doi: 10.1016/j.jemermed.2005.05.009.
2
Cardiac arrhythmia during propofol sedation.丙泊酚镇静期间的心律失常。
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3
Effect of propofol on seizure-like phenomena and electroencephalographic activity in children with epilepsy vs children with learning difficulties.丙泊酚对癫痫患儿与学习困难患儿癫痫样发作现象及脑电图活动的影响。
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Profiling adverse respiratory events and vomiting when using propofol for emergency department procedural sedation.在急诊科使用丙泊酚进行程序性镇静时分析不良呼吸事件和呕吐情况。
Emerg Med Australas. 2007 Oct;19(5):405-10. doi: 10.1111/j.1742-6723.2007.00982.x.
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Barriers to propofol use in emergency medicine.急诊医学中丙泊酚使用的障碍。
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6
Clinical practice advisory: Emergency department procedural sedation with propofol.临床实践指南:急诊科使用丙泊酚进行程序性镇静
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Emergency department procedural sedation with propofol: is it safe?急诊科使用丙泊酚进行程序性镇静:安全吗?
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Propofol for emergency department procedural sedation and analgesia: a tale of three centers.丙泊酚用于急诊科程序性镇静和镇痛:三个中心的故事
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Propofol by infusion protocol for ED procedural sedation.用于急诊科程序性镇静的丙泊酚输注方案。
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引用本文的文献

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Efficacy and Safety of Propofol as a Sole Sedative for fMRI Sedation in Autism Spectrum Disorder Individuals with Low IQ.丙泊酚作为单一镇静剂用于低智商自闭症谱系障碍个体功能磁共振成像镇静的疗效和安全性。
J Autism Dev Disord. 2025 Feb 11. doi: 10.1007/s10803-025-06742-x.
2
Intraoperative Seizure Under General Anesthesia Not Detected by EEG: A Case Report.脑电图未检测出的全身麻醉下术中癫痫发作:一例报告
Cureus. 2023 Jul 31;15(7):e42765. doi: 10.7759/cureus.42765. eCollection 2023 Jul.
3
A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.
钠通道介导丙泊酚诱导全身麻醉的潜在机制
Front Cell Neurosci. 2020 Dec 4;14:593050. doi: 10.3389/fncel.2020.593050. eCollection 2020.
4
Propofol effectively inhibits lithium-pilocarpine- induced status epilepticus in rats via downregulation of N-methyl-D-aspartate receptor 2B subunit expression.丙泊酚通过下调N-甲基-D-天冬氨酸受体2B亚基的表达有效抑制锂-匹罗卡品诱导的大鼠癫痫持续状态。
Neural Regen Res. 2012 Apr 15;7(11):827-32. doi: 10.3969/j.issn.1673-5374.2012.11.005.
5
Emergence delirium after propofol anaesthesia.丙泊酚麻醉后出现谵妄。
Eur J Clin Pharmacol. 2011 Feb;67(2):209-10. doi: 10.1007/s00228-010-0905-3. Epub 2010 Sep 28.
6
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens.递增剂量给予苯二氮䓬类药物和苯巴比妥的策略可减少震颤谵妄患者对机械通气的需求。
Crit Care Med. 2007 Mar;35(3):724-30. doi: 10.1097/01.CCM.0000256841.28351.80.