用油酸乙醇胺对口腔良性血管病变进行硬化治疗：一项针对30处病变的开放性临床试验。
Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: an open clinical trial with 30 lesions.
作者信息
Johann Aline Cristina Batista Rodrigues, Aguiar Maria Cássia Ferreira, do Carmo Maria Auxiliadora Vieira, Gomez Ricardo Santiago, Castro Wagner Henriques, Mesquita Ricardo Alves
机构信息
Department of Oral Surgery and Pathology, School of Dentistry, Federal University of the Minas Gerais, Minas Gerais, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):579-84. doi: 10.1016/j.tripleo.2004.12.021.
OBJECTIVE
The objective of this study was to report and discuss the results from treatment of benign oral vascular lesions with ethanolamine oleate.
STUDY DESIGN
Twenty-seven patients with 30 examples of oral vascular malformation, hemangioma, or varix were treated with intralesional injections of 1.25% or 2.5% ethanolamine oleate at an interval of 15 days between each application. The lesions were divided into 2 categories: (1) lesions of 20 mm or less and (2) those greater than 20 mm. Subsequently, the Mann-Whitney test was used a means of statistical analysis.
RESULTS
Although the number of injections varied from patient to patient, all lesions responded to the treatment, showing total clinical regression. Lesions of 20 mm or less needed a lesser number of applications than those greater than 20 mm (P < .05).
CONCLUSIONS
Ethanolamine oleate is a 100% effective sclerosant agent for treatment of benign oral vascular lesions. In this study, no difference was found between the 2 concentrations applied.
目的
本研究的目的是报告并讨论用油酸乙醇胺治疗口腔良性血管病变的结果。
研究设计
27例患者共30处口腔血管畸形、血管瘤或静脉曲张病变，采用瘤内注射1.25%或2.5%油酸乙醇胺治疗，每次注射间隔15天。病变分为两类：（1）20毫米或更小的病变；（2）大于20毫米的病变。随后，采用曼-惠特尼检验进行统计分析。
结果
尽管每位患者的注射次数不同，但所有病变对治疗均有反应，临床完全消退。20毫米或更小的病变比大于20毫米的病变所需注射次数更少（P < 0.05）。
结论
油酸乙醇胺是治疗口腔良性血管病变的100%有效的硬化剂。在本研究中，所应用的两种浓度之间未发现差异。
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