Bell Angus
Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin--Trinity College, Dublin 2, Ireland.
FEMS Microbiol Lett. 2005 Dec 15;253(2):171-84. doi: 10.1016/j.femsle.2005.09.035. Epub 2005 Oct 7.
Interactions between antimicrobial agents provide clues as to their mechanisms of action and influence the combinations chosen for therapy of infectious diseases. In the treatment of malaria, combinations of drugs, in many cases acting synergistically, are increasingly important in view of the frequency of resistance to single agents. The study of antimalarial drug interactions is therefore of great significance to both treatment and research. It is therefore worrying that the analysis of drug-interaction data is often inadequate, leading in some cases to dubious conclusions about synergism or antagonism. Furthermore, making mechanistic deductions from drug-interaction data is not straightforward and of the many reported instances of antimalarial synergism or antagonism, few have been fully explained biochemically. This review discusses recent findings on antimalarial drug interactions and some pitfalls in their analysis and interpretation. The conclusions are likely to have relevance to other antimicrobial agents.
抗菌药物之间的相互作用为其作用机制提供了线索，并影响用于治疗传染病的药物组合选择。在疟疾治疗中，鉴于对单一药物耐药性的频繁出现，药物组合（在许多情况下具有协同作用）变得越来越重要。因此，抗疟药物相互作用的研究对治疗和研究都具有重要意义。令人担忧的是，药物相互作用数据的分析往往不够充分，在某些情况下导致关于协同作用或拮抗作用的可疑结论。此外，从药物相互作用数据进行机制推导并非易事，在众多报道的抗疟协同作用或拮抗作用实例中，很少有从生化角度得到充分解释的。本综述讨论了抗疟药物相互作用的最新发现以及分析和解释中的一些陷阱。这些结论可能与其他抗菌药物相关。
