强力霉素在小鼠疟疾模型中的药效学
Pharmacodynamics of doxycycline in a murine malaria model.
作者信息
Batty Kevin T, Law Angela S F, Stirling Verity, Moore Brioni R
机构信息
School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, 6845 Western Australia, Australia.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4477-9. doi: 10.1128/AAC.00529-07. Epub 2007 Sep 17.
Abstract
Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.
摘要
据报道，强力霉素会损害第二代疟原虫的裂体增殖。在鼠疟模型中研究了单独使用强力霉素以及将其与双氢青蒿素联合使用的效果。强力霉素在2天内降低了疟原虫的生长速率，6天时效果最佳。添加双氢青蒿素产生了相加的抗疟作用。
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