强力霉素在小鼠疟疾模型中的药效学
Pharmacodynamics of doxycycline in a murine malaria model.
作者信息
Batty Kevin T, Law Angela S F, Stirling Verity, Moore Brioni R
机构信息
School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, 6845 Western Australia, Australia.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4477-9. doi: 10.1128/AAC.00529-07. Epub 2007 Sep 17.
Abstract
Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.
摘要
据报道，强力霉素会损害第二代疟原虫的裂体增殖。在鼠疟模型中研究了单独使用强力霉素以及将其与双氢青蒿素联合使用的效果。强力霉素在2天内降低了疟原虫的生长速率，6天时效果最佳。添加双氢青蒿素产生了相加的抗疟作用。
相似文献
1
Pharmacodynamics of doxycycline in a murine malaria model.强力霉素在小鼠疟疾模型中的药效学
Antimicrob Agents Chemother. 2007 Dec;51(12):4477-9. doi: 10.1128/AAC.00529-07. Epub 2007 Sep 17.
2
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.氯喹在小鼠疟疾模型中的药代动力学、药效学和体表面积比例缩放。
Antimicrob Agents Chemother. 2011 Aug;55(8):3899-907. doi: 10.1128/AAC.00067-11. Epub 2011 Jun 6.
3
Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.小鼠疟疾药效学模型及双氢青蒿素抗疟治疗的建立。
Int J Parasitol. 2007 Dec;37(14):1569-76. doi: 10.1016/j.ijpara.2007.05.001. Epub 2007 May 18.
4
Plasmodium berghei: parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model.伯氏疟原虫：在无脾小鼠疟疾模型中用双氢青蒿素治疗后的寄生虫清除情况。
Exp Parasitol. 2008 Apr;118(4):458-67. doi: 10.1016/j.exppara.2007.10.011. Epub 2007 Oct 22.
5
Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria.基于机制的寄生虫生长模型和二氢青蒿素在鼠疟中的药效动力学。
Antimicrob Agents Chemother. 2013 Jan;57(1):508-16. doi: 10.1128/AAC.01463-12. Epub 2012 Nov 12.
6
Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model.在小鼠疟疾模型中预测青蒿素联合疗法的杀寄生虫效果。
J Antimicrob Chemother. 2014 Aug;69(8):2155-63. doi: 10.1093/jac/dku120. Epub 2014 Apr 28.
7
Curcumin-artemisinin combination therapy for malaria.姜黄素-青蒿素联合疗法治疗疟疾。
Antimicrob Agents Chemother. 2006 May;50(5):1859-60. doi: 10.1128/AAC.50.5.1859-1860.2006.
8
Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model.青蒿素、双氢青蒿素和青蒿琥酯钠在伯氏疟原虫-啮齿动物模型中的体内和体外抗疟活性比较。
Int J Parasitol. 1994 Jul;24(4):589-94. doi: 10.1016/0020-7519(94)90150-3.
9
Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model.磷酸哌喹在小鼠疟疾模型中的药代动力学和药效学
Antimicrob Agents Chemother. 2008 Jan;52(1):306-11. doi: 10.1128/AAC.00878-07. Epub 2007 Nov 5.
10
[Pharmacodynamics of dihydroartemisinine against Plasmodium berghei in mice].二氢青蒿素对小鼠伯氏疟原虫的药效学
Yao Xue Xue Bao. 1989;24(7):487-9.
引用本文的文献
1
Fractional curative killing of pyronaridine or artesunate combinations with tafenoquine, 4-aminoquinolines, or azithromycin in a murine malaria-luciferase model.在小鼠疟疾-荧光素酶模型中，咯萘啶或青蒿琥酯与tafenoquine、4-氨基喹啉或阿奇霉素联合使用的分数治愈性杀伤作用。
Antimicrob Agents Chemother. 2025 Sep 3;69(9):e0024725. doi: 10.1128/aac.00247-25. Epub 2025 Jul 31.
2
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei.磷霉素和克林霉素对鼠疟原虫伯氏疟原虫的改良给药方案疗效
Int J Parasitol Drugs Drug Resist. 2025 Apr;27:100577. doi: 10.1016/j.ijpddr.2024.100577. Epub 2024 Dec 26.
3
Genetic-code-expanded cell-based therapy for treating diabetes in mice.基于遗传密码扩展细胞的疗法治疗小鼠糖尿病。
Nat Chem Biol. 2022 Jan;18(1):47-55. doi: 10.1038/s41589-021-00899-z. Epub 2021 Nov 15.
4
Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice.四环素衍生物可减少“黑暗中大量饮酒”小鼠的暴饮酒精行为。
Brain Behav Immun Health. 2020 Mar 19;4:100061. doi: 10.1016/j.bbih.2020.100061. eCollection 2020 Apr.
5
Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model.与青蒿琥酯、氯喹和阿莫地喹相比，焦宁单次给药在鼠疟荧光素酶模型中的药效学研究。
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00394-18. Print 2018 Sep.
6
Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.强力霉素通过减少炎症免疫反应和组织降解介质来抑制实验性脑型疟疾。
PLoS One. 2018 Feb 13;13(2):e0192717. doi: 10.1371/journal.pone.0192717. eCollection 2018.
7
Modelling the time course of antimalarial parasite killing: a tour of animal and human models, translation and challenges.疟原虫杀灭时间进程的建模：动物和人体模型、转化与挑战综述
Br J Clin Pharmacol. 2015 Jan;79(1):97-107. doi: 10.1111/bcp.12288.
8
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.氯喹在小鼠疟疾模型中的药代动力学、药效学和体表面积比例缩放。
Antimicrob Agents Chemother. 2011 Aug;55(8):3899-907. doi: 10.1128/AAC.00067-11. Epub 2011 Jun 6.
9
Piperaquine pharmacodynamics and parasite viability in a murine malaria model.在小鼠疟疾模型中哌喹的药效学及疟原虫生存力
Antimicrob Agents Chemother. 2009 Jul;53(7):2707-13. doi: 10.1128/AAC.00056-09. Epub 2009 Apr 20.
本文引用的文献
1
Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.小鼠疟疾药效学模型及双氢青蒿素抗疟治疗的建立。
Int J Parasitol. 2007 Dec;37(14):1569-76. doi: 10.1016/j.ijpara.2007.05.001. Epub 2007 May 18.
2
Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.四环素专门作用于疟原虫恶性疟原虫的顶质体。
Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31. doi: 10.1128/AAC.00394-06.
3
Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.包括甘氨酰环素在内的四环素类药物的药代动力学和药效学。
J Antimicrob Chemother. 2006 Aug;58(2):256-65. doi: 10.1093/jac/dkl224. Epub 2006 Jul 1.
4
Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.严重恶性疟联合治疗期间口服多西环素的药代动力学
Antimicrob Agents Chemother. 2005 Apr;49(4):1622-5. doi: 10.1128/AAC.49.4.1622-1625.2005.
5
The assessment of antimalarial drug efficacy.抗疟药物疗效的评估。
Trends Parasitol. 2002 Oct;18(10):458-64. doi: 10.1016/s1471-4922(02)02373-5.
6
Pharmacodynamic interaction of doxycycline and artemisinin in Plasmodium falciparum.强力霉素与青蒿素在恶性疟原虫中的药效学相互作用。
Antimicrob Agents Chemother. 2002 Jan;46(1):262-4. doi: 10.1128/AAC.46.1.262-264.2002.
7
Therapeutic responses to antibacterial drugs in vivax malaria.间日疟对抗菌药物的治疗反应。
Trans R Soc Trop Med Hyg. 2001 Sep-Oct;95(5):524-8. doi: 10.1016/s0035-9203(01)90027-6.
8
The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.青蒿琥酯联合标准抗疟药对恶性疟原虫氯喹敏感株和氯喹耐药株的体外作用。
Trans R Soc Trop Med Hyg. 1999 Jul-Aug;93(4):429-32. doi: 10.1016/s0035-9203(99)90147-5.
9
Assessment of the pharmacodynamic properties of antimalarial drugs in vivo.体内抗疟药物药效学特性评估。
Antimicrob Agents Chemother. 1997 Jul;41(7):1413-22. doi: 10.1128/AAC.41.7.1413.
10
Interaction of artemisinin and tetracycline or erythromycin against Plasmodium falciparum in vitro.青蒿素与四环素或红霉素在体外对恶性疟原虫的相互作用。
Parasite. 1994 Sep;1(3):211-8. doi: 10.1051/parasite/1994013211.
Zotero 插件