Huehn Jochen, Hamann Alf
Experimental Rheumatology, Charité University Medicine Berlin, c/o DRFZ, Schumannstr. 21/22, 10117 Berlin, Germany.
Trends Immunol. 2005 Dec;26(12):632-6. doi: 10.1016/j.it.2005.10.001. Epub 2005 Oct 21.
Compelling evidence suggests that diverse types of immune reactions can be suppressed by CD25+ CD4+ regulatory T cells (Tregs). Although increasing knowledge has accumulated concerning the generation and functional properties of Tregs, relatively little attention has been paid to another key question: where does immune regulation by Tregs take place in vivo? Tregs can inhibit both the priming and the effector phase of an immune response, so suppression might occur both within lymphoid tissues and at peripheral sites during immune reactions. This leads to the hypothesis that appropriate localization is indispensable for in vivo Treg function and that the migratory behavior of Treg subsets influences their in vivo suppressive capacity. Current data suggest a division of labor between subpopulations of Tregs, which is mainly based on specialized homing patterns.
有力证据表明，多种类型的免疫反应可被CD25 + CD4 +调节性T细胞（Tregs）抑制。尽管关于Tregs的产生和功能特性已有越来越多的认识，但另一个关键问题却相对很少受到关注：Tregs在体内何处进行免疫调节？Tregs既能抑制免疫反应的启动阶段，也能抑制效应阶段，因此抑制作用可能在淋巴组织内以及免疫反应期间的外周部位发生。这就引出了一个假说，即适当的定位对于Tregs的体内功能必不可少，并且Treg亚群的迁移行为会影响其体内抑制能力。目前的数据表明，Tregs亚群之间存在分工，这主要基于专门的归巢模式。
