Zhang Peiyan, Wang Jiawei, Miao Jinlin, Zhu Ping
Department of Clinical Immunology of Xijing Hospital and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China.
Front Immunol. 2025 Mar 6;16:1560578. doi: 10.3389/fimmu.2025.1560578. eCollection 2025.
Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues and influencing the progression of fibrosis. However, despite extensive research on how tissue Tregs interact with immune and non-immune cells during tissue repair, their pro- and anti-fibrotic effects in chronic tissue injury remain unclear. Understanding how tissue Tregs interact with various cell types, as well as their roles in chronic injury and fibrosis, is crucial for uncovering the mechanisms behind these conditions. In this review, we describe the roles of tissue Tregs in repair and fibrosis across different tissues and explore potential strategies for regulating tissue homeostasis. These insights hold promise for providing new perspectives and approaches for the treatment of irreversible fibrotic diseases.
组织驻留调节性T细胞（组织Tregs）对于维持免疫稳态和控制炎症至关重要。它们有助于修复受损组织并影响纤维化进程。然而，尽管对组织Tregs在组织修复过程中如何与免疫和非免疫细胞相互作用进行了广泛研究，但其在慢性组织损伤中的促纤维化和抗纤维化作用仍不清楚。了解组织Tregs如何与各种细胞类型相互作用，以及它们在慢性损伤和纤维化中的作用，对于揭示这些病症背后的机制至关重要。在这篇综述中，我们描述了组织Tregs在不同组织的修复和纤维化中的作用，并探讨了调节组织稳态的潜在策略。这些见解有望为治疗不可逆纤维化疾病提供新的视角和方法。
