Igarashi M, Shida T, Sasaki Y, Kinoshita N, Naganawa H, Hamada M, Takeuchi T
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1999 Oct;52(10):873-9. doi: 10.7164/antibiotics.52.873.
A new depsipeptide antibiotic, vinylamycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MI982-63F1, was identified as a member of Streptomyces. Vinylamycin was isolated from the culture broth by extraction with EtOAc and purified by crystallization from EtOAc. The structure of vinylamycin was determined by spectroscopic analysis and degradation studies. Vinylamycin showed antimicrobial activities against Gram-positive bacteria including MRSA.
一种新的缩肽抗生素——乙烯霉素，是从一株放线菌的培养液中分离出来的。产生该抗生素的菌株命名为MI982 - 63F1，被鉴定为链霉菌属的一个成员。通过用乙酸乙酯萃取从培养液中分离出乙烯霉素，并通过从乙酸乙酯中结晶进行纯化。通过光谱分析和降解研究确定了乙烯霉素的结构。乙烯霉素对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌具有抗菌活性。
