简化的乳腺癌原发性癌分级方法。
Simplified method of grading primary carcinomas of the breast.
作者信息
Parham D M, Hagen N, Brown R A
机构信息
Department of Pathology, Ninewells Hospital and Medical School, Dundee.
出版信息
J Clin Pathol. 1992 Jun;45(6):517-20. doi: 10.1136/jcp.45.6.517.
AIMS
To produce a simplified prognostic index for breast cancer.
METHODS
A retrospective study of 105 cases of primary infiltrating breast adenocarcinoma (not otherwise specified) was performed. Mitotic counts and semiquantitative assessment of tumour necrosis, fibrosis tubule formation, nuclear pleomorphism were made in histological sections of the primary tumour. Statistical analysis was performed to determine which of these parameters best predicts the observed survival.
RESULTS
Mitotic count and necrosis correlated best with survival. This allowed the formation of a simple prognostic index based on these two parameters.
CONCLUSIONS
This new prognostic index, with four tumour grades, seemed to be superior to Bloom's grading method, with greater separation of the prognostic groups. In particular, there is clear segregation of a group of patients with a distinctly poor prognosis.
目的
制定一个简化的乳腺癌预后指数。
方法
对105例原发性浸润性乳腺腺癌（未另作说明）进行回顾性研究。在原发性肿瘤的组织切片中进行有丝分裂计数以及对肿瘤坏死、纤维化、小管形成、核异型性进行半定量评估。进行统计分析以确定这些参数中哪一个最能预测观察到的生存率。
结果
有丝分裂计数和坏死与生存率的相关性最佳。这使得基于这两个参数形成了一个简单的预后指数。
结论
这个新的预后指数有四个肿瘤分级，似乎优于布卢姆分级法，预后组之间的区分度更大。特别是，有一组预后明显较差的患者有明显的区分。
Zotero 插件