Dixon J M, Page D L, Anderson T J, Lee D, Elton R A, Stewart H J, Forrest A P
Br J Surg. 1985 Jun;72(6):445-8. doi: 10.1002/bjs.1800720614.
A retrospective analysis of two groups of patients, one surviving 16-20 years and the other dying within 10 years after diagnosis and treatment of primary breast cancer has been undertaken to determine whether there were particular clinical or histological features associated with long-term survival. The striking histological difference between the tumours of the two groups of patients was the prevalence of tumours of 'special' invasive types (cribriform, tubular, lobular and medullary) in the long-term survivors. Micro-invasive and non-invasive carcinomas were also more common in the survivors. The tumours of the surviving group which were not of a 'special' type more commonly had a better histological grade than those tumours of patients dying early from breast cancer. In the overall group elastosis was present in significantly more tumours of the survivors whereas tumour necrosis, vascular and lymphatic invasion were all significantly more common in the short-term survival group. Although there was a significantly increased incidence of earlier stage tumours in the long-term survivors, the histological distinctions between the two groups were independent of the differences in clinical features.
对两组原发性乳腺癌患者进行了回顾性分析，一组存活16至20年，另一组在诊断和治疗后10年内死亡，以确定是否存在与长期存活相关的特定临床或组织学特征。两组患者肿瘤之间显著的组织学差异在于长期存活者中“特殊”浸润性类型（筛状、管状、小叶状和髓样）肿瘤的患病率。微浸润癌和非浸润癌在存活者中也更常见。存活组中不属于“特殊”类型的肿瘤，其组织学分级通常比早期死于乳腺癌患者的肿瘤更好。在总体组中，弹性组织变性在存活者的肿瘤中明显更多见，而肿瘤坏死、血管和淋巴管浸润在短期存活组中都明显更常见。尽管长期存活者中早期肿瘤的发病率显著增加，但两组之间的组织学差异与临床特征的差异无关。
