乳腺癌的形态计量分析：与生存的关联
Morphometric analysis of breast carcinoma: association with survival.
作者信息
Parham D M, Robertson A J, Brown R A
机构信息
Department of Pathology, University of Dundee, Scotland.
出版信息
J Clin Pathol. 1988 Feb;41(2):173-7. doi: 10.1136/jcp.41.2.173.
Abstract
In a retrospective study of 126 cases of infiltrating ductal adenocarcinoma of the breast the percentage area of sections of each neoplasm occupied by malignant cells was assessed by morphometry. The duration of postoperative survival was related to the area occupied by tumour cells within a neoplasm; the greater the tumour cell area to stroma the more prolonged the survival. This variable seemed to be independent of histological grade and was of greater prognostic importance than the diameter of the neoplasm. Furthermore, combination of percentage of tumour area with histological grade provided greater information on the survival characteristics of these patients. Extensive tumour necrosis was a particularly poor prognostic feature.
摘要
在一项对126例乳腺浸润性导管腺癌的回顾性研究中，通过形态计量学评估了每个肿瘤切片中恶性细胞所占的面积百分比。术后生存期与肿瘤内肿瘤细胞所占面积有关；肿瘤细胞面积与间质面积之比越大，生存期越长。这一变量似乎与组织学分级无关，并且比肿瘤直径具有更大的预后重要性。此外，肿瘤面积百分比与组织学分级相结合能提供关于这些患者生存特征的更多信息。广泛的肿瘤坏死是一个特别差的预后特征。
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本文引用的文献
1
LIFE EXPECTANCY FOLLOWING RADICAL AMPUTATION FOR CARCINOMA OF THE BREAST: A CLINICAL AND PATHOLOGIC STUDY OF 218 CASES.
Ann Surg. 1922 Jan;75(1):61-9.
2
The influence of the host and the neoplastic cell population on the collagen content of a tumor mass.
Cancer Res. 1963 May;23:648-53.
3
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.
Br J Cancer. 1957 Sep;11(3):359-77. doi: 10.1038/bjc.1957.43.
4
Prognostic value of measurement of elastosis in breast carcinoma.
J Clin Pathol. 1981 Jul;34(7):738-43. doi: 10.1136/jcp.34.7.738.
5
Prognostic indicators in breast cancer--morphometric methods.
Histopathology. 1982 May;6(3):327-39. doi: 10.1111/j.1365-2559.1982.tb02727.x.
6
A prognostic index in primary breast cancer.
Br J Cancer. 1982 Mar;45(3):361-6. doi: 10.1038/bjc.1982.62.
7
Intralaboratory variations in the grading of breast carcinoma.
Arch Pathol Lab Med. 1982 Mar;106(3):126-8.
8
Oestrogen receptor assay of cryostat sections of human breast carcinomas with simultaneous quantitative histology.
J Clin Pathol. 1983 Apr;36(4):399-405. doi: 10.1136/jcp.36.4.399.
9
Tumour cellularity, oestrogen receptors and prognosis in breast cancer.
Clin Oncol. 1983 Dec;9(4):311-8.
10
The pathological findings of breast cancer in patients surviving 25 years after radical mastectomy.
Cancer. 1982 Nov 15;50(10):2131-8. doi: 10.1002/1097-0142(19821115)50:10<2131::aid-cncr2820501027>3.0.co;2-a.
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