Parham D M, Robertson A J, Brown R A
Department of Pathology, University of Dundee, Scotland.
J Clin Pathol. 1988 Feb;41(2):173-7. doi: 10.1136/jcp.41.2.173.
In a retrospective study of 126 cases of infiltrating ductal adenocarcinoma of the breast the percentage area of sections of each neoplasm occupied by malignant cells was assessed by morphometry. The duration of postoperative survival was related to the area occupied by tumour cells within a neoplasm; the greater the tumour cell area to stroma the more prolonged the survival. This variable seemed to be independent of histological grade and was of greater prognostic importance than the diameter of the neoplasm. Furthermore, combination of percentage of tumour area with histological grade provided greater information on the survival characteristics of these patients. Extensive tumour necrosis was a particularly poor prognostic feature.
在一项对126例乳腺浸润性导管腺癌的回顾性研究中，通过形态计量学评估了每个肿瘤切片中恶性细胞所占的面积百分比。术后生存期与肿瘤内肿瘤细胞所占面积有关；肿瘤细胞面积与间质面积之比越大，生存期越长。这一变量似乎与组织学分级无关，并且比肿瘤直径具有更大的预后重要性。此外，肿瘤面积百分比与组织学分级相结合能提供关于这些患者生存特征的更多信息。广泛的肿瘤坏死是一个特别差的预后特征。
