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阿尔伯塔省城乡长期护理机构中抗精神病药物和苯二氮䓬类药物的使用:确保合理用药的教育干预措施的特点与结果

Neuroleptic and benzodiazepine use in long-term care in urban and rural Alberta: characteristics and results of an education intervention to ensure appropriate use.

作者信息

Hagen Brad F, Armstrong-Esther Chris, Quail Paddy, Williams Robert J, Norton Peter, Le Navenec Carole-Lynn, Ikuta Roland, Osis Maureen, Congdon Val, Zieb Roxane

机构信息

School of Health Sciences, The University of Lethbridge, Canada.

出版信息

Int Psychogeriatr. 2005 Dec;17(4):631-52. doi: 10.1017/S1041610205002188. Epub 2005 Oct 25.

Abstract

OBJECTIVES

To examine the use of psychotropic drugs in 24 rural and urban long-term care (LTC) facilities, and compare the effect of an education intervention for LTC staff and family members on the use of psychotropic drugs in intervention versus control facilities.

METHODS

Interrupted time series with a non-equivalent no-treatment control group time series. Data on drug use were collected in 24 Western Canadian LTC facilities (10 urban, 14 rural) for three 2-month time periods before and after the intervention. Pharmacy records were used to collect data on drug, class of drug, dose, administration, and start/stop dates. Chart reviews provided demographics, pro re nata (prn) use, and indications for drug use. Subjects comprised 2443 residents living in the 24 LTC facilities during the 1-year study. An average of 796.33 residents (32.7%) received a psychotropic drug. An education intervention on psychotropic drug use in LTC was offered to intervention physicians, nursing staff, pharmacists and family members.

RESULTS

Approximately one-third of residents received a psychotropic drug during the study, often for considerable lengths of time. A minority of psychotropic drug prescriptions had a documented reason for their use, and 69.5% of the reasons would be inappropriate under Omnibus Budget Reconciliation Act (OBRA) legislation. Few psychotropic drug prescriptions were discontinued or reduced during the study. More urban LTC residents received neuroleptics and benzodiazepines than their rural counterparts (26.1% vs. 15.7%, and 18.0% vs. 7.6%, respectively). The education intervention did not result in any significant decline in the use of these drugs in intervention facilities.

CONCLUSION

The results suggest substantial use of psychotropic drugs in LTC, although rural LTC residents received approximately half the number of psychotropic drugs compared with urban residents. A resource-intensive intervention did not significantly decrease the use of psychotropics. There is a need for better monitoring of psychotropic drugs in LTC, particularly given that voluntary educational efforts alone may be ineffective agents of change.

摘要

目的

调查24家城乡长期护理(LTC)机构中精神药物的使用情况,并比较针对LTC机构工作人员和家庭成员的教育干预措施对干预组和对照组机构中精神药物使用的影响。

方法

采用非等效无治疗对照组时间序列的中断时间序列设计。在干预前后的三个为期2个月的时间段内,收集了加拿大西部24家LTC机构(10家城市机构,14家农村机构)的药物使用数据。利用药房记录收集有关药物、药物类别、剂量、给药方式以及开始/停止日期的数据。通过病历审查获取人口统计学信息、必要时使用情况以及用药指征。在为期1年的研究中,研究对象包括居住在这24家LTC机构中的2443名居民。平均有796.33名居民(32.7%)使用了精神药物。针对LTC机构中精神药物的使用情况,对干预组的医生、护理人员、药剂师和家庭成员进行了教育干预。

结果

在研究期间,约三分之一的居民使用了精神药物,且用药时间通常较长。少数精神药物处方有记录在案的用药理由,而根据《综合预算协调法案》(OBRA)的规定,69.5%的用药理由并不恰当。在研究期间,很少有精神药物处方被停用或减量。城市LTC居民使用抗精神病药物和苯二氮䓬类药物的比例高于农村居民(分别为26.1%对15.7%,以及18.0%对7.6%)。教育干预并未使干预组机构中这些药物的使用量显著下降。

结论

结果表明LTC机构中大量使用精神药物,尽管农村LTC居民使用的精神药物数量约为城市居民的一半。一项资源密集型干预措施并未显著减少精神药物的使用。需要对LTC机构中的精神药物进行更好的监测,特别是考虑到仅靠自愿性教育努力可能无法有效改变现状。

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