Ruths S, Straand J, Nygaard H A
Department of Public Health and Primary Health Care, University of Bergen, Norway.
Eur J Clin Pharmacol. 2001 Sep;57(6-7):523-8. doi: 10.1007/s002280100348.
Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed.
A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics, anxiolytics, hypnotics, antidepressants, and two sedative antihistamines) was analysed with regard to prevalence, diagnostic indications, duration of use, and general patient- and institution characteristics.
Psychotropic drugs were taken on a daily schedule by 59% of all residents, most commonly as long-term treatment. Antidepressants (in 70% selective serotonin re-uptake inhibitors) were used by 31%, neuroleptics by 23%, and benzodiazepines by 22% of all the residents. Neuroleptics were given for non-psychotic behavioural and psychological symptoms in 66% of the cases. Sleeping disorders were most commonly treated with long-acting benzodiazepine hypnotics. Psychotropic drug use decreased with increasing patient age. Drug use patterns varied greatly between the different nursing homes: the prevalence of neuroleptic use varied from 0 to 61% of the residents, and antidepressant use varied from 10 to 63%. In nursing homes providing relatively more physician staff time, the residents were more likely to use antidepressants.
Psychotropic drugs are used by a majority of nursing home residents as long-term symptomatic treatment. The great variations between the institutions can only to a small extent be explained by quantitative differences between the institutions.
分析养老院居民使用精神药物的诊断指征以及患者和机构特征。
对挪威卑尔根23家养老院1552名居民的用药数据进行横断面研究。分析了精神药物(抗精神病药、抗焦虑药、催眠药、抗抑郁药和两种镇静性抗组胺药)的使用情况,包括患病率、诊断指征、使用时长以及患者和机构的一般特征。
59%的居民每日服用精神药物,最常见的是长期治疗。所有居民中,31%使用抗抑郁药(70%为选择性5-羟色胺再摄取抑制剂),23%使用抗精神病药,22%使用苯二氮䓬类药物。66%的病例中,抗精神病药用于治疗非精神病性的行为和心理症状。睡眠障碍最常使用长效苯二氮䓬类催眠药治疗。精神药物的使用随患者年龄增长而减少。不同养老院之间的用药模式差异很大:抗精神病药的使用患病率在居民中的比例从0%到61%不等,抗抑郁药的使用比例从10%到63%不等。在医生工作时间相对较多的养老院,居民更有可能使用抗抑郁药。
大多数养老院居民使用精神药物进行长期对症治疗。机构之间的巨大差异只能在很小程度上由机构之间的数量差异来解释。