Kristal B S, Yu B P
Department of Physiology, University of Texas Health Science Center, San Antonio.
J Gerontol. 1992 Jul;47(4):B107-14. doi: 10.1093/geronj/47.4.b107.
Most modern theories of aging have centered around the notion that age-related deterioration is primarily due to structural and functional modifications of cellular constituents. Among them are three currently popular hypotheses--the Free Radical, Glycation, and Maillard Theories of Aging. The first proposes that age-related effects are due to free radical reactions that damage cellular constituents, while the latter propose damage induced by nonenzymatic glycation and other Maillard reactions and the consequent modification of macromolecules as the primary cause of aging. Although these hypotheses were formulated independently, recent studies suggest that free radicals, glycation, and Maillard reactions may in fact represent partially interactive elements of a single, more complex biochemical pathway. We therefore propose the Free Radical-Glycation/Maillard Reaction Theory of Aging: that age-related deterioration is produced by the sum of the damage induced by free radicals, by glycation, by Maillard reactions, and by their interactions.
大多数现代衰老理论都围绕着这样一个概念，即与年龄相关的衰退主要是由于细胞成分的结构和功能改变。其中包括目前流行的三种假说——衰老的自由基假说、糖基化假说和美拉德反应假说。第一种假说认为，与年龄相关的影响是由于自由基反应损害细胞成分所致，而后者则提出非酶糖基化和其他美拉德反应引起的损害以及由此导致的大分子修饰是衰老的主要原因。尽管这些假说是独立提出的，但最近的研究表明，自由基、糖基化和美拉德反应实际上可能代表了一个更复杂的单一生化途径中部分相互作用的元素。因此，我们提出衰老的自由基-糖基化/美拉德反应理论：与年龄相关的衰退是由自由基、糖基化、美拉德反应及其相互作用所诱导的损害总和产生的。
