Raithel M, Baenkler H W, Naegel A, Buchwald F, Schultis H W, Backhaus B, Kimpel S, Koch H, Mach K, Hahn E G, Konturek P C
Department of Medicine I, Gastroenterology, Functional Tissue Diagnostics, Erlangen University, Germany. Martin.Raithel@ med1.imed.uni-erlangen.de
J Physiol Pharmacol. 2005 Sep;56 Suppl 5:89-102.
Salicylate intolerance is defined as a nonspecific antigen-induced pseudo-allergic hypersensitivity reaction which can occur upon contact of an organism with salicylic acid, its derivatives or other related organic or inorganic acids of similar chemical structure. Since the effects of nonsteroidal anti-inflammatory drugs (NSAID) intolerance are by no means always severe or life-endangering but may just as well present as oligosymptomatic or local disorders (e.g. abdominal pain, diarrhea, we decided to evaluate the characteristics of patients with salicylate intolerance on the basis of gastroenterological case material of Medical Department I of Erlangen University. On the basis of the findings from the Erlangen interdisciplinary data register of chronic inflammatory gastrointestinal disease, the signs and symptoms of NSAID intolerance were found to constitute a diagnosis of great practical import to clinical medicine (allergology, dermatology, immunology, other disorders etc.) including gastroenterology. For approx. 2-7% of all patients with inflammatory bowel syndrome and food allergies this poses a new diagnostic and therapeutic challenge which may concern physicians from any of the disciplines involved. When presented with patients with chronic active disease who are suffering from these symptoms one should, therefore, in future give greater thought to the possibility of salicylate intolerance, all the more as there are meaningful dietetic, diagnostic and therapeutic options available for these persons.
水杨酸盐不耐受被定义为一种非特异性抗原诱导的假性过敏超敏反应，当生物体接触水杨酸、其衍生物或其他化学结构相似的相关有机或无机酸时可能会发生。由于非甾体抗炎药（NSAID）不耐受的影响并非总是严重或危及生命，也可能表现为症状较少或局部病症（如腹痛、腹泻），我们决定根据埃尔朗根大学第一医学部的胃肠病学病例资料评估水杨酸盐不耐受患者的特征。根据埃尔朗根慢性炎症性胃肠病跨学科数据登记处的研究结果，发现NSAID不耐受的体征和症状对临床医学（过敏学、皮肤病学、免疫学、其他病症等）包括胃肠病学具有重要的实际诊断意义。对于约2%-7%的炎症性肠综合征和食物过敏患者而言，这带来了新的诊断和治疗挑战，可能涉及任何相关学科的医生。因此，当面对患有这些症状的慢性活动性疾病患者时，未来应更多地考虑水杨酸盐不耐受的可能性，尤其是因为有针对这些人的有意义的饮食、诊断和治疗选择。
