Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.

作者信息

Ferreira Fernando, Morvan François

机构信息

Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université de Montpellier U1, Place E. Bataillon, 34095 Montpellier Cedex 5, France.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1009-13. doi: 10.1081/ncn-200060342.

DOI:10.1081/ncn-200060342

PMID:16248081

Abstract

An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disulfide linkage with TCEP. The olgonucleotide was obtained without any basic treatment.

摘要

相似文献

Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1009-13. doi: 10.1081/ncn-200060342.

A novel amino-on CPG-support for the synthesis of 3'-aminoalkylated oligonucleotides.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):989-92. doi: 10.1081/ncn-200059388.

Generation of an abasic site in an oligonucleotide by using acid-labile 1-deaza-2'-deoxyguanosine and its application to postsynthetic modification.

Org Lett. 2005 Feb 17;7(4):709-12. doi: 10.1021/ol0474498.

Oxidation of biotin during oligonucleotide synthesis.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):919-22. doi: 10.1081/ncn-200059277.

Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):691-4. doi: 10.1081/ncn-200060267.

A steroid cap adjusts the selectivity and accelerates the rates of nonenzymatic single nucleotide extensions of an oligonucleotide.

J Am Chem Soc. 2001 Dec 19;123(50):12718-9. doi: 10.1021/ja011448i.

Solid-phase synthesis of backbone-modified DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases.

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3783-6. doi: 10.1016/j.bmcl.2008.05.053. Epub 2008 May 17.

The synthesis of diene-containing nucleoside phosphoramidites and their use in the labeling of oligonucleotides.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):761-5. doi: 10.1081/ncn-200060085.

Microwaves synthesis of solid supports for the synthesis of 3'-aminoalkyl oligodeoxynucleotides.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):623-7. doi: 10.1081/ncn-200059394.

Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):739-41. doi: 10.1081/ncn-200060048.

引用本文的文献

Traceless Staudinger Ligation to Access Stable Aminoacyl- or Peptidyl-Dinucleotide.

ACS Omega. 2023 Jan 17;8(4):3850-3860. doi: 10.1021/acsomega.2c06135. eCollection 2023 Jan 31.

Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase.

Nucleic Acids Res. 2022 Jun 10;50(10):5793-5806. doi: 10.1093/nar/gkac354.

Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs.

Org Lett. 2012 May 18;14(10):2488-91. doi: 10.1021/ol300777p. Epub 2012 May 3.

Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.

J Am Chem Soc. 2008 Jul 23;130(29):9556-65. doi: 10.1021/ja802118p. Epub 2008 Jun 28.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验